摘要
脂肪干细胞(adipose-derived stem cells,ADSCs)具有来源广泛、易于获取、体外扩增、免疫原性低等许多优于其他组织来源间充质干细胞(mesenchymal stem cells,MSCs)的特点,越来越多的研究开始关注如何将其应用于组织损伤的治疗与修复。就近几年来国内外ADSCs的发现与分离、向肌腱谱系分化能力以及在肌腱损伤修复方面的应用进行了综述,分析了ADSCs应用于肌腱损伤修复时的优势和面临的问题,并对未来的研究方向进行了展望。
Adipose-derived stem cells（ ADSCs） have more advantages than other tissue derived mesenchymal stem cells（ MSCs）,such as a wide range of sources,easy to acquire,amplification in vitro,as well as low immunogenicity,etc. More and more studies begin to pay close attention to how they can be applied to the treatment and regeneration of tissue damage. This paper reviewed the discovery and separation of ADSCs,and their differentiation ability towards tendon lineage,as well as the application in the aspect of tendon injuries both at home and abroad in recent years. The paper also analyzed the advantages and problems of ADSCs application. At last the future research direction was prospected.
作者
汪晶晶
马月辉
关伟军
WANG Jingjing;MA Yuehui;GUAN Weijun(titute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;Harbin Sport University, Harbin 150008, China)
出处
《生物技术进展》
2018年第1期7-13,共7页
Current Biotechnology
基金
国家自然科学基金项目(31672404)
中国农业科学院科技创新工程项目(cxgc-ias-01)资助
关键词
脂肪干细胞
多向分化
肌腱损伤修复
组织工程
种子细胞
adipose-derived stem cells
multilineage differentiation
tendon repair and regeneration
tissue engineering
seed cell
