醒脑静注射液联合吡拉西坦对脑出血患者血浆NSE水平及认知功能障碍的影响

Efficacy of Xingnaojing injection combined with Piracetam in treatment of cerebral hemorrhage and its effect on plasma NSE level and cognitive impairment in patients

目的:探讨醒脑静注射液联合吡拉西坦治疗脑出血的效果及对患者血浆神经元特异性烯醇化酶(NSE)及认知功能障碍的影响。方法:将脑出血后认知功能障碍90例患者纳入研究并随机分组,对照组45例用吡拉西坦,观察组45例联合醒脑静注射液静脉滴注,1个月为1个疗程。比较治疗前后简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(Mo CA)评分及运动功能(ADL评分)改善情况,比较两组NSE改善及临床疗效差异。结果:治疗后,患者Mo CA、MMSE及ADL评分升高,NSE水平降低,与治疗前比较P<0.05;治疗后,观察组Mo CA、MMSE、ADL评分更高,NSE更低,与对照组比较P<0.05;对照组总有效率73.33%(33/45),观察组91.11%(41/45),两组比较P<0.05。结论:醒脑静注射液联合吡拉西坦治疗脑出血效果显著,可有效改善认知功能,促进神经功能恢复。

Objective：To investigate the efficacy of Xingnaojing injection combined with Piracetam in the treatment of cerebral hemorrhage and its effect on plasma neuron specific enolase （NSE） and cognitive impairment in patients. Methods：Ninety patients with cognitive impairment after cerebral hemorrhage were State Examination （MMSE） score, Montreal Cognitive Assessment （MoCA） score and improvement in motor function （ADL score） were compared before and after treatment. Improvement in NSE and clinical efficacy were compared between the two groups. Results：After treatment, MoCA, MMSE and ADL scores in the two groups increased,NSE level decreased, while compared to before treatment （P〈0.05）. After treatment, MoCA, MMSE and ADL scores in the observation group were higher while NSE was lower as compared with the control group （P〈0.05）. Total effective rate in the control group and the observation group was 73.33% （33/45） and Conclusion ： Xingnaojing injection 91.11% （41/45）, presenting a combined with Piracetam in the significant difference （ P 〈 0.05 ）. treatment of cerebral hemorrhage presents significant efficacy, and can effectively improve cognitive function and promote neural function recovery.