糖化血红蛋白和血清C肽检测对糖尿病患者的诊断价值及临床意义

Diagnostic value and clinical significance of glycosylated hemoglobin and serum C-peptide in diabetic patients

目的:探讨糖化血红蛋白(HbA1c)和血清C肽联合检测在糖尿病患者中诊断价值及临床意义。方法:选择2型糖尿病(T2DM)患者82例为研究对象,根据患者是否合并有糖尿病并发症分为A组(合并有糖尿病并发症,31例)和B组(单纯T2DM,51例),选取同期我院体检中心体检健康志愿者50名作为C组,检测并比较3组研究对象空腹血糖(FBG)、餐后2 h血糖(2 h PG)、HbA1c和血清C肽水平。结果:A、B两组患者FBG、2 hPG水平均高于C组(P<0.05),A、B两组患者FBG、2 hPG水平比较差异无统计学意义(P>0.05)。A、B、C 3组HbA1c水平依次降低,血清C肽水平依次升高,组间各值比较差异均有统计学意义(P<0.05)。结论:HbA1c和血清C肽联合检测在糖尿病诊断及病情严重程度判定方面均有较高临床价值。

Objective：To investigate the diagnostic value of glycated hemoglobin （HbAlc） and serum C- peptide in diabetic patients and its clinical significance. Meth0ds：82 case of type 2 diabetes mellitus （T2DM） patients were selected as study object, divided them into group A （with complications of diabetes, 31 cases） and group B （T2DM alone, 51 cases）, in the same period, our hospital physical examination center health volunteers 50 as C group, the levels of fasting blood glucose （FBG） , 2 h postprandial blood glucose （2 hPG）, HbAlc and serum C peptide levels were measured and compared. Results：The levels of FBG and 2 hPG in group A and B we~ higher than those in group C （P〈0.05）. There was no Significant difference in FBG and 2 hPG between the A and B groups（P〉0.05）. The levels of HbAlc in group A, B and C were decreased and the levels of serum C-peptide were increased, and the values among these groups were statistically significant （P〈0.05）. Conclusion： HbAIc and serum C peptide combined detection in the diagnosis of diabetes and the severity of the disease have a higher clinical value.