镁离子对脑缺血保护作用的研究进展

Research Progress of magnesium ions neuroprotection in brain ischemia

脑缺血后的神经保护疗法是当今脑卒中治疗的重要手段之一。缺血后脑神经元可发生一系列病理学改变,若不能及时干预,最终对神经细胞造成不可逆性损伤。镁离子作为一种内源性保护因子,可通过多种途径干预脑缺血引起的神经损伤通路。大量基础研究发现,镁离子可减少脑缺血动物的脑梗死体积,改善神经行为能力;然而临床试验结果显示,镁离子并不能降低脑卒中患者的病死率与残疾率。针对此矛盾性,笔者就补镁疗法在脑缺血疾病领域的基础与临床研究概况作一综述。

Neuroproteetive therapy after cerebral ischemia is one of the important means of treatment of cerebral apoplexy. A series of pathological changes can occur after cerebral ischemia. If not timely intervention, neurons would sufter irreversible damage eventually. As a endogenous protective factor, magnesium ions can interfere the nerve damage pathway through various channels intervenllon in cerebral isehemia. A large number of basic studies found that magnesium ions can reduce ischemie cerebral infarction volume we found magne contradiction, pa and improve neurobehavioral ability. However, according to the results of clinical trials, sium ion does not reduce mortatity and disability in patients with stoke. For this per reviews the filling of magnesium therapy in the basic and clinical researeh of cerebral ischemia disease.