基于“白术、桑白皮”配伍规律探讨桑白皮性味拆分组分的可组合性

Based on the compatibility law of Amk and MC,discussed on the combination of the components of the flavor and flavor components of MC

目的基于"白术、桑白皮"配伍规律的桑白皮性味拆分组分的可组合性研究,初步验证"药性(气)与药味的物质基础是可拆分、可组合的"中药性味理论新假说的客观性。方法检测24h尿蛋白、白蛋白(ALB)、甘油三酯(TG)、总胆固醇(TC)、肌酐(Cr)、低密度脂蛋白(LDL-C)和尿素氮(BUN)的水平。结果与NC组相比,M组大鼠24h尿蛋白、TC、TG、BUN、Cr含量显著性升高(P<0.01),ALB水平显著性降低(P<0.01);与M组相比,降低模型大鼠24h尿蛋白含量、血清TC、TG、BUN、Cr、LDL-C的含量(P<0.01或P<0.05),升高ALB含量(P<0.05)。Am K∶MC-30组干预作用最佳。结论初步推测桑白皮30%乙醇洗脱组分基本能代替桑白皮产生的配伍作用,为中药性味拆分组分可组合的合理性提供理论依据以及为阐明中药药性理论的科学内涵奠定了一定的基础。

Objective The aim of this study is to investigate compatibility of effective flavor split fractions of Mori Cortex, Rhizo- ma Atractylodis macrocephalae on Adriamycin （ADR） -induced nephropathy rats and providing theoretical basis for the research of the combination of the components of the property and flavor. Methods Adriamycin nephrotic syndrome in rats model, 24 h u-rine protein of rats, the levels of serum creatinine （Cr） , urea nitrogen （BUN） , triglycerides （TG） ,low density lipoprotein（ LDL - C ） total cholesterol （TC） and albumin （ALB） to filtering out the best combination effect. Results Compared with the normal group, the levels of Cr,TC, TG, BUN and 24h in the model group were significantly increased （P 〈0; 01 ）, and the level of ALB was significantly lower （ P 〈 0.01 ）. Each drug administration group could down - regulated the level of 24h urinary protein, TC, TG, BUN LDL - C and Cr obviously （ P 〈 0.01 or P 〈 0.05 ）, up - regulated the level of Alb obviously （ P 〈 0.05 ）. Conclusion The MC - 30 ： AmK - Pol has the best Anti - nephrotic - syndrome effect, And flavor components can be combined.