隔姜灸联合盐酸坦索罗辛胶囊治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)临床疗效及机制研究

Therapeutical Effect and Mechanism Study of Using Ginger-partitioned Moxibustion Combined with Tamsulosin in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome ( CP/CPPS) Patients

目的:观察隔姜灸联合盐酸坦索罗辛胶囊治疗CP/CPPS患者的治疗效果及可能的机制。方法:将CP/CPPS患者360例随机分为实验组120例,对照组120例及空白对照组120例。实验组予口服盐酸坦索罗辛胶囊,每次0.2mg,每日1次,并行隔姜灸治疗,每日1次。对照组仅口服盐酸坦索罗辛胶囊,每次0.2mg,每日1次。空白对照组不给于任何关于CP/CPPS相关治疗处理。三组均治疗30天。观察治疗后各组患者临床症状的改善情况、EPS中WBC阳性例数、EPS中TNF-α、IL-1β、卵磷脂小体含量变化及外周血中CD3^+、CD4^+、CD8^+、CD4^+CD25^+、CD4^+CD25^+Foxp3^+、TGF-β1的表达水平。结果:治疗后,实验组NIH-CPSI总体评分明显低于对照组及空白对照组;实验组EPS中卵磷脂小体含量明显高于对照组及空白对照组;实验组EPS中炎性因子TNF-α、IL-1β水平明显低于对照组及空白对照组;治疗组EPS中WBC阳性总例数由治疗前的86例减少为治疗后的20例,明显优于对照组及空白对照组;治疗后实验组及对照组患者外周血CD3^+、CD4^+、CD8^+、CD4^+CD25^+、CD4^+CD25^+Foxp3^+、TGF-β1含量均明显提高,但治疗后实验组水平均明显高于对照组及空白对照组。结论:隔姜灸可显著改善CP/CPPS患者的临床症状,其治疗作用可能与隔姜灸提高患者的免疫功能有关。

Objective ： To study the therapeutical effect and mechanism of ginger-partitioned moxibustion combined with tamsulosin on CP/CPPS patients. Methods： We randomly divided 360the type CP/CPPS patients into experimental, controlled and blank controlled groups, two groups were treated with oral administration of the tamsulosin for 30days （0. 2mg, 1/d）, and the experimental group was treated with ginger-partitioned moxibustion at the same time. After treatment, we observed the im- provements of clinical symptoms and the changes of thelevels of CD3 ＋, CD4 ＋, CD5 ＋, CD4 ＋ CD25 ＋, CD4 ＋ CD25＋ Foxp3 ＋ , trans- forming growth factor （TGF） -β1in the three groups. Results： After treatment, the total efficiency in the experimental group was higher than that of the controlled group and blank controlled group; the NIH-CPSI scores, TNF-α, IL-1βlevels in EPS from the experimental group were significantly lower than those in the controlled group and blank controlled group ; the WBC posi- tive total number of cases in the experimental group from 86cases before treatment reduced to 26cases, were significantly higher than that in the controlled group and the blank control group ; the levels of seminal plasma lecithin body in the experimental group were higher than that in the controlled group and blank controlled group. At last, the levels of CD3 ＋ , CD4 ＋, CD5 ＋, CD4 ＋ CD25 ＋, CD4 ＋ CD25 ＋ Foxp3 ＋, TGF-β1 from the experimental group were much higher than those in the cotrolled group and blank controlled group. Conclusion： Ginger-partitioned moxibustion can improve clinical symptoms of CP/CPPS patients, these results may be associated with the improving of patients＇ immune function.