首发儿童青少年精神分裂症患者临床用药分析与比较

Clinical Drug Use in Children and Adolescent with First-Episode Schizophrenia

目的:探讨首发儿童青少年精神分裂症患者的临床用药及疗效。方法:回顾性调查2015年1月至2016年12月我院96例首发儿童青少年精神分裂症住院患者(儿童组)的临床用药资料、疗效及不良反应,并与98例首发成人精神分裂症患者(成人组)比较。结果:两组患者均以单一用药、第二代抗精神病药为主,抗精神病药物的剂量无显著差异,儿童组的锥体外系反应和催乳素水平升高不良反应显著多于成人组,合并使用苯海索或普萘洛尔的患者也显著多于成人组。结论:首发儿童青少年精神分裂症患者对抗精神病药物不良反应较为敏感,建议单一使用第二代抗精神病药物,无效时可辅以无抽搐电休克治疗。

Objective：To investigate the clinical drug use and efficacy of the first-episode children and adolescents schizophrenia.Methods：The clinical data,efficacy and adverse reactions of hospitalized patients of 96 first-episode children and adolescent（children group） with schizophrenia were retrospectively from 2015 to 2016,and compared with those of 98 adults cases（adults group）.Results：The two groups of patients were mainly treated with a single medication and the second generation antipsychotic drugs.There were no significant differences between the doses of antipsychotic drugs.The adverse effects of extrapyramidal side effect and prolactin levels in the children group were significantly higher than those in the adult group,and patients with combined use of diphenhydramine or propranolol were significantly more than those in the adult.Conclusion：The first episode of schizophrenia in children and adolescents is more sensitive to adverse reactions,it is recommended to single use the second generation antipsychotic drugs,and can be treated with modified electric convulsive therapy when invalid.