特应性体质肺炎支原体感染患儿临床特点及血清IL-17的水平研究

Clinical characteristics of Mycoplasma pneumoniae infection in atopic constitution children and serum IL-17 level

目的分析特应性体质患儿肺炎支原体感染的临床特点、常规实验室指标及血清白细胞介素-17(IL-17)水平,为特应性体质肺炎支原体感染患儿诊疗提供依据。方法选取医院2016年1月-2017年1月期间收治的肺炎支原体感染患儿151例,按照是否为特应性体质,分为特应性体质肺炎支原体感染患儿61例(研究组),非特应性体质肺炎支原体感染患儿90例(对照组);分析两组患儿性别、年龄、住院时间、发病时间等临床资料,对患儿胸腔积液例数、胸片类型、既往特应性皮炎、变应性鼻炎、家族过敏史、既往哮喘病史、糖皮质激素及吸氧治疗等临床特点进行分析比较。比较两组患儿常规指标及血清IL-17水平。结果两组患儿性别、年龄、住院时间、发病时间差异无统计学意义;两组患儿胸腔积液例数、胸片类型及既往特应性皮炎、鼻炎和家族过敏史差异均无统计学意义;研究组患儿既往哮喘病史、糖皮质激素及吸氧治疗例数均高于对照组(P<0.05);两组患儿常规指标L、WBC、LogTEC、N、CRP、PLT差异无统计学意义;研究组LDH水平、血清总IgE高于对照组患儿,血清IL-17水平低于对照组患儿(P<0.05)。结论特应性体质肺炎支原体感染患儿病情较非特应性体质肺炎支原体感染患儿严重,这与其体内血清IL-17水平较低存在密切联系。

OBJECTIVE To investigate the clinical characteristics of Mycoplasma pneumoniae infection in atopic constitution children and the levels of routine laboratory indexes and serum interleukin-17（IL-17）so as to provide guidance for diagnosis and treatment of the atopic constitution children with M.pneumoniae infection.METHODS A total of 151 children with M.pneumoniae infection who were treated in the hospital from Jan 2016 to Jan 2017 were enrolled in the study and divided into two groups according to the status of atopic constitution,61 children with M.pneumoniae infection who were atopic constitution were assigned as the study group,and 90 children with M.pneumoniae infection who were not atopic constitution were set as the control group.The clinical data of the two groups of children,including gender,age,length of hospital stay and onset time,were analyzed;the clinical characteristics such as number of cases of hydrothorax,type of chest X-ray,previous atopic dermatitis,allergic rhinitis,family allergy history,previous asthma history,glucocorticoids and oxygen inhalation therapy were observed and compared among the children;the levels of routine indexes and serum IL-17 were compared between the two groups of children.RESULTS There was no significant difference in the gender,age,length of hospital stay or onset time between the two groups of children.There was no significant difference in the number of cases of hydrothorax,type of chest X-ray,previous atopic dermatitis,rhinitis or family allergy history between the two groups of children.The number of the patients who had the previous asthma history or received glucocorticoids or oxygen inhalation therapy was significantly larger in the study group than in the control group（P〈0.05）.There were no significant differences in the routine indexes L,WBC,LogTEC,N,CRP and PLT between the study group and the control group.The levels of LDH and serum total IgE of the study group were higher than those of the control group,and the serum IL-17 level of the study group was significantly lower than that of the control group（P〈0.05）.CONCLUSIONThe illness condition of the atopic constitution children with M.pneumoniae infection is more severe than that of the non-atopic constitution children with M.pneumoniae infection,which is closely associated with the serum IL-17 level.