孕妇晚期服用肠道益生菌对新生儿免疫功能的影响

Effects of oral intestinal probiotics for late pregnant women on the immune function of newborns

目的针对孕晚期产妇给予添加肠道益生菌,观察其对新生儿免疫功能的影响。方法选择佳木斯大学附属第一医院产科门诊自2016年11月起建档的产妇,自妊娠28周开始口服肠道益生菌至妊娠至少37周,且于妊娠≥37周时行择期剖宫产术的产妇30例为实验组,选择妊娠≥37周未服用药物的行择期剖宫产术的产妇30例为对照组。同时收集剖宫产新生儿脐带血3ml,采用流式细胞技术检测T细胞亚群CD_4^+、CD_8^+及CD_4^+/CD_8^+含量,采用免疫浊度分析仪检测免疫球蛋白IgA、IgM、IgG的含量。结果实验组IgA、IgM与对照组相比差异无统计学意义(P>0.05),实验组IgG与对照组相比显著升高(P<0.001);实验组CD_4^+与对照组相比显著降低(P<0.001),实验组与对照组相比CD_8^+显著升高(P<0.001),实验组CD_4^+/CD_8^+与对照组相比降低(P<0.001)。结论孕晚期产妇口服肠道益生菌可增强新生儿免疫力,对孕产妇及新生儿大有禆益。

Objective To observe the effects of complement of oral intestinal probiotics to late pregnancy women on the immune function of the newborns. Methods Pregnant women registered in files of Outpatient Obstetrics First Affiliated Hospital of Jiamusi University from November 2016 were selected.Thirty puerperas who kept taking oral intestinal probiotics from 28 th week to at least 37 th week pregnancy and underwent elective cesarean section were enrolled in the experimental group,and 30 puerperas who didn＇t take oral intestinal probiotics and underwent elective cesarean section were selected as control group.At the same time,3 ml umbilical cord blood of cesarean section newborns from each newborn was collected.T cell subgroup CD4^＋,CD8^＋and CD4^＋/CD8^＋contents were detected by using flow cell technology,and immunoglobulin IgA,Ig M and IgG contents were detected by immunoturbidity analyzer. Results Comparison of IgA and IgM between the experimental group and the control group showed that there were no statistically significant differences（P〈0.05）.The IgG in experimental group increased significantly by comparison with the control group（P〈0.001）;the CD4^＋in the experimental group decreased significantly by comparison with the control group（P〈0.001）;the CD8^＋in the experimental group significantly increased by comparison with control group（P〈0.001）;the CD4^＋/CD8^＋in the experimental group decreased by comparison with the control group（P〈0.001）. Conclusion Oral intestinal probiotics for late pregnancy women can enhance the immunity of newborns,which can benefit the puerperas and newborns a lot.