弥散加权成像-液体衰减反转恢复序列不匹配在觉醒型卒中的应用进展

Advancements of Diffusion Weighted Imaging and Fluid Attenuated Inversion Recovery Mismatch in Wake-up Ischemic Stroke

觉醒型卒中是一种在睡眠中起病的缺血性卒中,发病时间窗的判断较困难,静脉溶栓治疗决策困难。近年来,弥散加权成像(diffusion weighted imaging,DWI)-液体衰减反转恢复序列(fluid attenuated inversion recovery,FLAIR)不匹配作为一种判断觉醒型卒中发病时间窗的客观影像学指标被广泛运用。本文概述DWI-FLAIR不匹配的基本原理,分析其应用价值,通过对比觉醒型卒中和发病时间明确的缺血性卒中的临床和影像学特点,探讨该技术指导静脉溶栓治疗的可行性及应用现状。

Wake-up stroke,with an unknown time of onset during sleep,is a type of ischemic stroke.Limited by the onset time window,intravenous thrombolysis is difficult to implement.As an objective imaging index for judging the time window of the onset of stroke,diffusion weighted imaging（DWI）-fluid attenuated inversion recovery（FLAIR） mismatch has been widely used in recent years.This paper will give a brief overview of the basic principle of DWI-FLAIR mismatch and analysis of its application value,and explore the feasibility and application status of its technology in guiding intravenous thrombolytic therapy of wake-up ischemic stroke by comparing the clinical and imaging characteristics of ischemic stroke with clear onset time window.