固冲汤联合炔诺酮治疗围绝经期无排卵性功血的临床观察

The Clinical observation of Guchong decoction combined with norethindrone in the treatment of Perimenopausal Anovulatory Dysfunctional Uterine Bleeding

目的观察固冲汤联合炔诺酮治疗围绝经期无排卵性功血的临床效果。方法选择围绝经期无排卵性功能失调性子宫出血79例患者分为2组。治疗组予以中药固冲汤联合炔诺酮治疗,对照组单用炔诺酮治疗。结果 2组患者治疗前子宫内膜厚度差异无统计学意义(P>0.05),治疗后子宫内膜厚度均变薄,治疗组(P<0.05)和对照组(P<0.05),其中治疗组治疗后子宫内膜厚度较对照组明显变薄,差异有统计学意义(P<0.05);2组患者治疗前血红蛋白值比较差异无统计学意义(P>0.05),治疗后2组血红蛋白均较治疗前显著上升(P<0.05),中药固冲汤联合炔诺酮治疗绝经期功血患者血红蛋白提升效果优于对照组(P<0.05);治疗前2组患者的凝血酶原时间(APTT)、部分凝血酶原时间(PT)比较差异无统计学意义(P>0.05);治疗后APTT、PT均较治疗前降低,差异有统计学意义(P<0.05),治疗组治疗后APTT下降明显低于对照组(P<0.05)。结论中药固冲汤联合炔诺酮治疗围绝经期无排卵性功血的临床效果明显优于单用炔诺酮。

Objective To observe the clinical effect of Guchong decoction combined with norethindrone in the treatment of Perimenopausal Anovulatory Dysfunctional Uterine bleeding. Methods 79 cases of anovulatory dysfunctional uterine bleeding in perimenopausal period were divided into two groups. The treatment group was treated with traditional Chinese medicine decoction combined with levonorgestrel. The control group was treated with levonorgestrel alone. Results The endometrial thickness was no significant difference between the two groups before treatment （P 〉 0.05 ）. After treatment, the endometrial thickness became thin, Guchong decoction combined with norethindrone group （P 〈 0.05 ） and norethindrone group （P 〈 0.05 ）, The endometrial thickness in Guchong decoction combined with norethindrone group was significantly thinner than that of the control group, the difference was statistically significant（ P 〈 0. 05 ）. After treatment,the hemoglobin of two groups were increased significantly compared with those before treatment（P 〈 0.05） ,Chinese medicine Guchong decoction combined with norethindrone in treating menopausal dysfunctional uterine bleeding patients improve hemoglobin was superior to the control group（ P 〈 0.05 ）. Prothrombin time of two groups of patients before treatment （APTT） and Partial thromboplastin time （PT） had no significant difference（P 〉 0.05 ）, APTT and PT after treatment were lower than those before treatment,the difference was statistically significant （ P 〈 0.05 ）, APTT decreased in traditional Chinese medicine Guchong decoction combined with norethindrone group after treatment was significantly lower than the control group（ P 〈 0.05）. Conclusion Clinical effect of Chinese herbal medicine Guchong decoction combined with norethindrone in the treatment of Perimenopausal Anovulatory Dysfunctional uterine bleeding is better than the single use of norethisterone.