银川市医院体检回汉族人群高尿酸血症患病率及其相关因素的研究

The research of prevalence and correlative factors of hyperuricemia in Hui and Han populations in Yinchuan

目的探讨4家医院体检的回汉族人群高尿酸血症(HUA)的患病率及其与血压、血脂、血糖、体重指数等水平变化的相关性。方法采用抽样调查方法检测22 843例(其中回族2 456例、汉族20 387例)20~60岁银川市回汉族居民血尿酸、体重指数、血压、血脂、血糖及是否伴有脂肪肝、烟酒嗜好等,对其相关性进行分析。结果 HUA患者3 993例,患病率17.48%(男性21.70%,女性13.10%),其中回族365例,患病率14.9%;汉族3628例,患病率17.8%,汉族人群与回族人群相比,汉族人群HUA患病率显著增高(P<0.05)。HUA患病者3 993例,按照年龄段分组比较,发病最多的为20岁~,其次为51岁~年龄段。HUA患者与血尿酸正常者相比,其收缩压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、血糖、体重指数均明显增高,差异有统计学意义(P<0.05);高密度脂蛋白胆固醇明显降低(P<0.05),脂肪肝的发病率明显增高(P<0.05)。汉族和回族的HUA患者,其血压、体重指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇均较健康组高(P<0.05),低密度脂蛋白胆固醇较健康组低(P<0.05),脂肪肝发病率较健康组高(P<0.05)。血尿酸水平增高者,其血压、体重指数、脂代谢、糖代谢及脂肪肝观察指标的异常率高(P<0.05)。民族、体重指数、总胆固醇、甘油三酯、高密度脂蛋白、血糖、高血压是影响HUA的独立因素,其中民族和血糖是HUA的保护性因素,其余因素是HUA的独立危险因素。结论银川市回汉族居民HUA患病率处于较高水平,其中汉族发病率明显高于回族人群(P<0.05),肥胖、高血压、糖脂代谢紊乱、脂肪肝是HUA的共同病变基础。

Objective To investigate the prevalence rate of Hyperuricemia （HUA） in Ningxia Hui Autonomous Region and the relevance between Hyperuricemia （HUA）, blood pressure （BP） ,lipid levels, blood glucose and body mass index （BMI）. Methods A total of 22843 Yinchuan Hui and Han residents from 20 to 60 years old were surveyed. The HUA, BMI, BP, lipid levels, blood glucose were tested in order to find whether the residents was accompanied by fatty liver and the habit of smoking and alcohol. Which analyzed by Analysis of Variance,x2 test,t test and Logistic regression ana/ysis. Result There were 3993 eases who have been diagnosed HUA and the prevalance rate was 17.48% （ male 21.70% ,female 13.1% ）. The HUA prevalanee rate of Hui and Han were 14.9% and 17.8% , Han was significantly higher than Hui（ P 〈 0. 05 ）. There were 3993 persons who have been diagnosed HUA who were divided into four age groups,the higher prevalence of HUA was 51 to 60 years old, secondly was 20 to 30 years old. For patients with HUA, the SBP,TC, TG, LDL,blood glucose and BMI were higher than those people without HUA, there was great significantly difference （P 〈 0. 05 ） ;HDL were obviously decreased （P 〈 0. 05 ）, the incidence of fatty liver significantly increased（ P 〈 0. 05 ） ;on the other hand, the HUA patients of Hui and Han people has the same result. In the hihger serum uric acid level, the observation index＇ s abnormal rates of their BP, BMI, lipid metabolism, glycometabolism and fatty liver was higher（ P 〈 O. 05 ）. Ethnic, BMI, TC, TG, HDL, Blood glucose, hypertension were the independent factors,while ethnic and blood glucose were the protection factors and others were the risk factors. Conclusion The prebalence rate of HUA in Yinchuan city keeps in a higher level, It＇ s higher in Han people （P 〈 0. 05 ）. Also, obesity, hypertension, disorders of glucose and lipid metabolism and fatty liver are the basis for the development of HUA.