地方性砷中毒所致皮肤损伤及其发病机制研究进展

Skin lesions caused by endemic arsenicosis and pathogenesis： a review

地方性砷中毒（简称地砷病）是由慢性砷暴露引起的一种严重危害人体健康的地方病，皮肤是其重要的靶器官，临床诊断主要依赖典型的皮肤三联征（掌跖角化、皮肤色素沉着和色素脱失），但发病机制一直不明确。目前虽然有一些关于地砷病所致皮肤病变的研究文章，但是系统的综述还很缺乏。通过对地砷病皮肤病变的相关文献进行归纳，从地砷病所致皮肤病变相关的流行病学、病理改变以及发病机制3个方面进行阐述，希望加深人们对地砷病皮肤损伤的认识。为地砷病的研究提供一些新的思路与线索。

Endemic arsenicosis is a kind of endemic diseases, which is caused by chronic arsenic exposure and is seriously harmful to human health. Skin is the important target organ of endemic arsenicosis. Clinical diagnosis for this endemic disease mainly depends on the cutaneous triad （hyperkeratosis on the palms and soles, cutaneous hyper-pigmentation and hypo-pigmeutation）. But the pathogenesis of this disease is still unclear. In-depth understanding of the skin lesions and the pathogenesis is greatly significant for the scientific explanation of endemic arsenicosis. Although there are some studies on the skin lesions caused by endemic arsenicosis, a systematic review is still lacking. In this paper, the epidemiology, pathological changes and pathogenesis of skin lesions caused by endemic arsenicosis are summarized. Here we expect this summarization will deepen the understanding on skin lesions caused by endemic arsenicosis and provide some new ideas and clues for other researchers.