病毒性心肌炎与细胞死亡机制

Role of cell death mechanism in viral myocarditis

病毒性心肌炎是由病毒感染引起的一种非特异性心肌炎症，10％～20％的病例最终发展为扩张型心肌病。病毒感染心肌的初期即对心肌造成直接损伤，持续存在的炎性反应及持续的病毒感染诱导机体发生的免疫反应间接损伤心肌，导致心肌进一步损伤。在心肌炎的进程中伴随着心肌细胞的死亡，其方式包括凋亡、自噬、坏死、程序性坏死等。现阐述细胞死亡在病毒性心肌炎发生发展过程中的作用及机制。

Viral myoearditis is a nonspeeific myocardial inflammation caused by viral infection, 10% - 20% of them can develop to dilated eardiomyopathy eventually. Virus infections caused direct myocardial damage as they at- tack. Persistent inflammation and persistent virus infections induced an immune inflammation response and eventually caused indirectly damage,leading to further harm to myocardia. Different forms of cell death including apoptosis, autoph- agy, necrosis and necroptosis were associated with myocarditis. The role and mechanism of different cell death in the development of viral myoearditis will be described.