外周血多配体蛋白聚糖-1浓度变化对系统性硬皮病相关性肺动脉高压的评价意义

Significance of changes in blood syndecan-1 in evaluating pulmonary arterial hypertension related to systemic sclerosis

目的:探讨系统性硬皮病(SSc)患者外周血多配体蛋白聚糖(Syn)-1与SSc肺动脉高压的关系。方法:采用酶联免疫吸附试验(ELISA)检测40例患者组和30例正常对照组血清Syn-1浓度,分析其与SSc患者一氧化碳弥散量(DLCO)和右心室收缩压(RVSP)的关系。结果:患者组血清Syn-1浓度[(72.27±9.20)μg/L]较正常对照组[(49.73±8.75)μg/L]明显升高(P<0.01)。RVSP升高患者血清Syn-1浓度[(85.92±7.48)μg/L]高于RVSP正常患者[(68.21±4.60)μg/L](P<0.01)。Syn-1升高患者RVSP升高发生率[50.00%(6/12)]及DLCO降低发生率[41.67%(5/12)]分别高于Syn-1正常患者[均为10.71%(3/28)](P均<0.05)。SSc患者血清Syn-1浓度与其RVSP呈正相关(r=0.81,P<0.01);与DLCO呈负相关(r=-0.581,P<0.01)。结论:Syn-1可能参与SSc疾病的发生及发展,血清Syn-1水平的增高对评估SSc相关性肺动脉高压的病情活动有临床意义。

Objective： To investigate the relationship between the serum levels of syndecan（Syn）-I and pulmonary arterial hypertension in patients with systemic sclerosis（SSc）. Methods： ELISA assay was used to measure serum levels of Syn-1 in patients with active SSc and normal controls, and the correlations of Syn-1 with the DLCO and RVSP were also analyzed. Results： Serum levels of Syn-1 in patients with SSc[（72.27±9.20）μg/L] were significantly higher than that in normal controls [（49.73±8.75） μg/L, P〈0.01]. Serum levels of Syn-1 in the SSc patients with elevated RVSP were higher than that in the SSc patients with normal RVSP[（85.92±7.48） μg/L vs. （68.21±4.60）μg/L, P〈0.01]. The incidences of elevated RVSP（50.0%） and decreased DLCO （41.67%） were higher in the patients with elevated Syn-I levels than that in patients with normal Syn-1 levels（both 10.71%, P〈0.05）. The serum levels of Syn-1 were ly correlated with DLCO in the SSc patients （r=0,81,P〈0.01） SSc. Increased serum Svn-1 levels are associated with disease positively correlated with RVSP（r=0.81,P〈0.01）, and negative- Conclusion： Syn-1 may be involved in the development of activity of SSc-associated ~ulmonarv hypertension.