注射透明质酸钠凝胶修复退缩牙龈乳头初探

Clinical evaluation of reconstruction of interdental papilla with hyaluronic acid gel

目的本研究通过局部注射透明质酸钠凝胶,观察其短期修复退缩的牙龈乳头的临床疗效。方法 5名女性志愿者的前牙美学区共16个牙龈乳头退缩位点符合标准被纳入研究,局麻后在退缩位点注射透明质酸钠凝胶,3周和6周时在原位点再重复注射1次。治疗前及末次注射后6个月分别拍摄照片,使用图像软件测量牙龈乳头垂直高度的恢复和邻面间隙暴露面积的减少量并进行统计分析。结果牙龈乳头高度注射后6个月与基线比较,牙龈乳头高度平均增加0.62 mm,牙龈乳头高度变化率均值为27.3%。邻面间隙暴露面积平均减少0.67 mm^2,邻面间隙暴露面积减少率平均为50.9%。注射前后牙龈乳头高度和邻面间隙暴露面积的变化均有统计学意义(P<0.01)。结论局部注射透明质酸钠凝胶可能是微创修复退缩牙龈乳头的有效方法,其修复能力和长期疗效有待更大规模的临床随机对照研究加以证实。

Objective To evaluate the short-term efficacy of enhancing deficient interdental papilla of anterior teeth with hyaluronic acid gel injection. Methods 16 target sites with interdental papilla recession were treated in five female volunteers. Following local an- esthesia, cross-linked sodium hyaluronate gel was injected into the base of every defective papilla. The injections were repeated twice three weeks and six weeks later. Papillary heights and lost papilla surface areas were calculated from digital clinical photographs taken at base line and 6 months after operation using image software Digimizer. The comparsion of the changes of papillary height and the lost papilla surface areas between baseline and postoperativetime points were statistically analyzed. Results The average difference in height of the target inderdental papilla between baseline and 6 month after operation was 0.62 mm. The percentage of the height change between baseline and postoperative visit was 27.3%, The average change of the lost papilla surface area was 0.67mm2. The mean per- centage of area change was 50.9%. Differences between baseline and postoperative visit were statistically significant（ P〈 0.01 ）. Con- elusions Use of hyaluronic acid gel to treat interdental papilla recession resuhes in significant improvement after 6 months.