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蚕丝/PGA针织医用支架的体外降解行为研究 被引量:1

In vitro degradation behavior of PGA/silk knitted scaffold
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摘要 采用蚕丝和聚羟基乙酸(PGA)长丝以0∶6和3∶3两种不同比例制备了2种编织线,再以这2种编织线为原料在小口径针织机上制备针织支架。将两种支架浸入PBS(pH为7.4)中,放入培养箱,在温度为37℃的条件下,放置0、1、2、3周拍摄扫描电镜照片来观察其表面结构形态,放置0、0.5、1、1.5、2、2.5、3周测试其失重和断裂强力。研究表明:在3周降解过程中,3 PGA/3蚕丝比6 PGA支架降解的速度慢,3 PGA/3蚕丝支架的质量损失率低于6 PGA编织线,3 PGA/3蚕丝支架强力保持率高于6 PGA支架。 Two kinds of braided yarns are prepared by weaving silk with different proportions of silk and polyglycolic acid (PGA) filaments of 0 : 6 and 3 : 3. The two kinds of scaffolds are immersed in PBS (pH 7.4) and placed in the incubator at 37℃. The surface morphology is observed in 0, 1, 2 and 3 weeks and scanned in 0, 0.5,1, 1.5, 2, 2.5, 3 weeks respectively to test its weight loss and breaking strength. The results show that the degradation rate of PGA/silk scaffold is slower than that of pure PGA scaffold during 3 weeks. The quality loss rate of pure PGA scaffold is more than that of PGA/silk scaffold, and the strength retention rate of PGA/silk scaffold is higher than that of pure PGA scaffold.
作者 郭正 谢娟
出处 《上海纺织科技》 北大核心 2018年第1期19-20,42,共3页 Shanghai Textile Science & Technology
基金 河南省高等学校青年骨干教师资助计划
关键词 蚕丝 聚羟基乙酸 针织 支架 降解 silk polyglycolic acid knitting scaffold degradation
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