玻璃体腔注射康柏西普治疗视网膜静脉阻塞继发黄斑水肿的疗效观察

Efficacy of intravitreal conbercept injection on macular edema secondary to retinal vein occlusion

目的评估玻璃体腔注射康柏西普治疗视网膜静脉阻塞(RVO)继发黄斑水肿的有效性。方法回顾分析我院玻璃体腔注射康柏西普治疗经眼底血管造影确诊的RVO继发黄斑水肿患者33例(33眼)。观察治疗前及治疗后1周、2周、4周、3个月、6个月的最佳矫正视力(BCVA)、眼压、裂隙灯显微镜、间接检眼镜、光学相干层析成像、荧光素眼底血管造影检查,对比分析治疗前后患者BCVA及黄斑中心视网膜厚度(CMT)的改变。结果玻璃体腔注射康柏西普,与治疗前相比,治疗后1周、2周、4周、3个月、6个月BCVA提高,CMT降低,差异均有统计学意义。结论玻璃体腔注射康柏西普治疗RVO继发黄斑水肿短期内有效,可促进水肿吸收,提高视力,而多次注射问题和潜在并发症仍有待解决。

Objective To observe the efficacy of intravitreal conbercept injection on macular edema secondary to retinal vein occlusion （RVO）. Methods Thirty-three patients with macular edema secondary to RVO confirmed by fundus fluorescein angiography received intravitreal injection of conbercept. Before and after the treatment 1 week, 2 weeks, 4 weeks, 3 months, 6 months, best corrected visual acuity （BCVA）, intraocular pressure, slit lamp microscope, indirect ophthalmoscope, optical coherence tomography, fluorescein fundus angiography were observed. The changes in BCVA and central retinal macular thickness （CMT） were analyzed before and after the treatment. Results Intravitreal injection of conbercept treatment for 1 week, 2 weeks, 4 weeks, 3 months and 6 months, B CVA improved and CMT decreased, with the differences were statistically significant. Conclusions Intravitreal injection of conbercept is effective for macular edema caused by RVO in the short term, promoting the absorption of edema, improving eyesight, and repeatedly injections, potential complications remain to be resolved.