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我如何治疗FLT3-ITD突变阳性急性髓系白血病 被引量:2

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摘要 FLT3基因编码的酪氨酸激酶参与造血发育。在急性髓系白血病(AML)患者中存在两种FLT3基因突变:一种为FLT3基因激酶区的点突变(TKD),另一种为FLT3基因内部串联重复(ITD)。1996年一个日本研究组在研究将FLT3mRNA作为微小残留病检测指标时发现了FLT3-ITD突变。这类突变是FLT3基因的近膜区序列ITD,为非移码突变,
作者 王建祥
出处 《中华血液学杂志》 CAS CSCD 北大核心 2018年第1期1-4,共4页 Chinese Journal of Hematology
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