闭环肌松注射与持续输注罗库溴铵对甲状腺癌临床效果的比较

Clinical Efficacy of Rocuronium Through Close-loop Muscle Relaxant Injection and Continuous Infusion for Thyroid Carcinoma

目的对比分析全身静脉麻醉下闭环肌松注射与持续输注罗库溴铵对甲状腺癌的效果。方法 82例符合入选标准的患者随机分为闭环肌松注射组(CL组)和静脉持续输注组(CI组),记录插管时间、苏醒时间、拔管时间、罗库溴铵总药量、插管条件评分和出室时镇静评分,并记录两组患者手术期间肌松不良事件的发生率。结果与CI组相比,CL组插管时间明显较长(P<0.01),苏醒时间和拔管时间缩短(P<0.01),插管评分较高(P<0.01),且CL组中罗库溴铵的用量减少(P<0.01),术中肌松不良事件也较CI组得到改善(P<0.05),Steward苏醒评分无明显差别(P>0.05)。结论闭环式肌松注射系统使罗库溴铵用于甲状腺癌术中,药物用量减少且肌松恢复更快,有利于实现精准给药。

Objective To observe the efficacy of rocuronium through close-loop muscle relaxant injection and continuous infusion by total intravenous anesthesia （TIVA） with thyroid carcinoma surgery. Methods A total of 82 patients scheduled for thyroid surgery were randomly divided into 2 groups：group CL received rocuronium by closed-loop muscle relaxant injection, group CI received rocuronium by continuous infusion. Intubation time ,extubation time, analepsia time, total dosages of rocironium, intubation condition score and sedation scores out of room were compared between the 2 groups,while the incidence of inadequate surgical relaxation during surgery was recorded. Results Compared with group CI, Intubation time was longer, extubation time and analepsia time in group CL were significantly shorter,intubation condition score was better, the dosage of rocironium was obviously less （P 〈 0.01 ）, meanwhile the incidence of inadequate surgical relaxation was reduced in group CL（ P 〈 0.05 ）, Sedation scores out of room had no significant difference between the 2 groups （ P 〉 0.05 ）. Conclusion Close-loop muscle relaxant injection in thyroid carcinoma surgery, could make the dosage of rocironium less and patients recover faster,which is beneficial for precise anesthesia.