35岁以下宫颈癌患者的临床发病因素分析及其预后

Analysis of Influential Factors of Clinical Onset and Prevention and Treatment of Cervical Cancer Patients Under 35

目的探讨35岁以下宫颈癌患者临床病理特点及预后情况。方法回顾性分析80例35岁以下宫颈癌患者的临床病理特点及预后情况(观察组),并选择80例35岁及以上宫颈癌患者为研究对照组,分析与比较2组临床特点及影响因素。结果经研究分析发现,2组患者避孕药使用史、初次性交≤20岁、HPV感染史、临床分期、肿瘤大小、病理类型、浸润深度及淋巴结转移情况相比,存在明显差异(P<0.05)。观察组患者5年生存率明显低于对照组,2年内复发率明显高于对照组,P<0.05。经Logistic多因素回归分析发现,35岁以下宫颈癌患者5年生存期的高危因素为临床分期(B=0.927)、浸润深度(B=1.873)、淋巴结转移(B=1.254),P<0.05。结论 35岁以下宫颈癌患者临床病理特点为临床分期晚且恶性程度高,影响因素较多,且预后较差,因此加强早期筛查及诊治十分关键。

Objective To investigate the clinicopathological features and prognosis of cervical cancer patients under 35. Methods 80 cases of cervical cancer patients under 35 were retrospectively analyzed, and 80 cases of cervical cancer over 35 years were selected as the control group. The clinical characteristics and influencing factors of the 2 groups were analyzed and compared. Results There were significant differences between the 2 groups in the history of contraceptive use,the history of first sexual intercourse ≤20, HPV infection history, clinical stage, tumor size, pathological type, depth of invasion and lymph node metastasis. The 5-year survival rate of the observation group was significantly lower than that of the control group （ P 〈 0.05 ）, and the 5-year survival rate in the observation group was significantly lower than that of the control group, The 2-year recurrence rate was significantly higher than the control group, P 〈0. 05. The multivariate logistic regression analysis showed that the risk factors of 5- year survival of patients under 35 was clinical stage （ B = 0. 927 ）, depth of invasion （ B = 1. 873 ）, lymph node metastasis （ B = 1. 254） ,P 〈0.05. Conclusion The clinical and pathological features of cervical cancer in patients under 35 are early stage of malignancy, more influencing factors and poor prognosis. Therefore, it is very important to strengthen early screening and diagnosis and treatment.