替加环素药物利用评估标准的建立及应用

Establishment and Application of DUE Criteria for Tigecycline

目的:为临床合理应用替加环素提供参考。方法:以替加环素药品说明书为基础,参考相关规范和文献,并通过与临床专家讨论协商,从用药指征、用药过程、用药结果和行政监管4个方面建立替加环素药物利用评估(DUE)标准;同时,采用回顾性调查方法,对我院2015年1月-2016年12月使用替加环素的住院患者病历应用该DUE标准进行评估。结果:共纳入使用替加环素的住院患者病历71份。经评估我院替加环素使用总体基本符合该DUE标准的要求,但尚存在一些不合理情况,包括微生物送检率为81.7%(目标值为90%),给药疗程符合标准率为76.1%(目标值为90%),病历中有会诊记录的患者比例为81.7%(目标值为100%),处方权限符合标准率为85.9%(目标值为100%)。结论:所建立的替加环素DUE标准有较强的可操作性和实用性,可为医师和临床药师开展相关工作提供参考。

OBJECTIVE： To provide reference for rational use of tigecycline. METHODS： Based on tigecycline instructions, referring to related specifications and literatures, through pharmacy and clinical expert discussion, DUE criteria for tigecycline was established from medication indications, medication process, medication results and administrative supervision. In retrospective study, DUE criteria was used to evaluate medical records of inpatients in our hospital during Jan. 2015-Dec. 2016. RESULTS： A total of 71 medical records of inpatients receiving tigecycline were included. The use of tigecycline in our hospital was basically up to DUE criteria. But there still was unreasonable phenomenon, such as microbial inspection rate was 81.7% （aiming at 90% ）; the rate of medication course meeting the criteria was 76.1% （aiming at 90% ） ; the proportion of patients with consultation records was 81.7% （aiming at 100% ） ; the rate of prescribing authority meeting the criteria was 85.9% （aiming at 100% ）. CONCLUSIONS： The established DUE criteria for tigecycline shows strong operability and practicability, and provide reference for the work development of doctors and clinical pharmacists.