摘要
A dermatan sulfate （DS） repeating disaccharide analog, β-L-idopyranosiduronate-（1→3）-2-amino-2- deoxy-4,6-di-O-sulfo-β-D-galactopyranoside, has been convergently synthesized and successfully applied to prepare the GAG-functionalized gold glyconanoparticle. This new material exhibited good anti-inflammatory activity which was comparable to that of the drug ibuprofen incarrageenan-induced paw edema in a rat model.
A dermatan sulfate （DS） repeating disaccharide analog, β-L-idopyranosiduronate-（1→3）-2-amino-2- deoxy-4,6-di-O-sulfo-β-D-galactopyranoside, has been convergently synthesized and successfully applied to prepare the GAG-functionalized gold glyconanoparticle. This new material exhibited good anti-inflammatory activity which was comparable to that of the drug ibuprofen incarrageenan-induced paw edema in a rat model.
基金
supported in partial by the National Natural Science Foundation of China(Nos.21232002,21372254,21621064 and 21672255)
