羊藿巴戟口服液联合舍曲林治疗早泄的临床疗效观察

目的观察中成药羊藿巴戟口服液与舍曲林联合用药治疗早泄的临床疗效。方法收集2016年12月至2017年5月就诊的早泄患者共80例，将其分为A组即观察组（羊藿巴戟口服液＋舍曲林）和B组即对照组（舍曲林），每组各40例。观察组给予羊藿巴戟口服液10ml／次，每天早中晚三次口服，联合舍曲林50mg／次，1次／d，口服，持续治疗8周对照组服用舍曲林50mg，1次／d，持续治疗8N。治疗期间尽量增加性交次数。比较治疗前后阴道内射精时间（IELT）、CIPE-5评分、性生活满意度和不良反应。结果治疗8N后观察组的IELT由（1．69±0．635）min延长至（4．85±0．502）min，对照组的IETL由（1．77±0．690）min延长至（4．77±0494）min，两组均能均能提高IELT，但观察组优于对照组（P〈0．05）。观察组治疗后CIPE-5评分由（24．92±4．401）分提高至（37．2±6．263）分，对照组治疗后CIPE-5评分由（25．26±4．242）分提高至（3566±7．690）分，两组均提高CIPE-5评分，但观察组优于对照组（P〈0．05）。观察组与对照组的性生活满意度得分均由2分左右提高至3．5分。观察组治疗总有效率达到85％，高于对照组的80％（P〈0.05）。治疗过程未见患者出现恶心呕吐、心悸、失眠、焦虑等不良反应。结论羊藿巴戟口服液与舍曲林联合治疗早泄有效且安全。

Objective To observe the clinical curative effect of traditional Chinese medicine Epimedium officinalis oral liquid and sertraline in the treatment of premature ejaculation. Methods A total of 80 patients with premature ejaculation were enrolled in the period from December 2016 to May 2017, they were divided into group A treatment group （ Epimedium officinalis oral liquid ＋ sertraline ） and B group that control group （sertraline） , 40 cases in each group. In the end of the experiment, 40 patients in each group completed the trial.The treatment group received Epimedium officinalis oral liquid 10ml, three times a day, combined with sertraline 50mg each time, once a day, oral, continuous treatment for 8 weeks. The control group took sertraline 50rag, daily 1 time, continuous treatment for 8 weeks. The intrauterine ejaculation time （ IELT ） , CIPE-5 score, sexual life satisfaction and adverse reactions were compared before and after treatment. Results After 8 weeks of treatment, the IELT of the treatment group was prolonged from （ 1.69 ± 0.635 ） min to （4.85 ±0.502 ） rain. The IETL of the control group was prolonged from （ 1.77 ±0.690 ） min to （4.77± 0.494 ） min. Both groups could prolong IELT, but the treatment group was superior to the control group （P〈0.05） . The CIPE-5 score increased from （24.92±4.401 ） to （37.2± 6.263 ） after treatment, and the CIPE-5 score increased from （ 25.26 ± 4.242 ） to （ 35.66± 7.690 ） in the control group. Both groups could improve the CIPE-5 score. The treatment group was superior to the control group （P〈0.05） . The scores of sexual life satisfaction of the treatment group and the control group were increased from about 2 points to 3.5 points. The total effective rate of the treatment group was 85%, which was higher than that of the control group （P〈0.05） . No nausea, vomiting, palpitation, insomnia, anxiety and other adverse reactions occurred in the course of treatment. Conclusion Epimedium officinalis oral liquid combined with sertraline is safe and effective in the treatment of premature ejaculation.