华法林治疗糖尿病周围神经病变的临床效果分析

目的观察以华法林辅助治疗2型糖尿病周围神经病变的临床疗效。方法将2013年1月5：．2014年1271收治的105例糖尿病周围神经病变患者，随机分为观察组（n=53）和对照组（n=52），对照组使用常规基础治疗，观察组在对照组的基础上使用华法林治疗，3-5月为1个疗程，治疗结束后评价其治疗效果。结果正中神经和腓总神经的运动传导速度（MNCV）均有明显升高，且观察组均高于对照组；正中神经和腓总神经的感觉传导速度（SNCV）均有明显升高，且观察组均高于对照组，差异有统计学意义（P〈0．05）。观察组治疗显效30例．好转17例，无效6例，总有效率88％；对照组显效104例，好转15例，无效27例，总有效率48％。两组比较差异有统计学意义（P〈0．05）。结论华法林治疗2型糖尿病周围神经病变临床效果确切，能够提高患者的生活质量。

Objective To observe the the clinical curative effect of using warfarin as a main drag to treat type2 diabetes patients with diabetic peripheral neuropathy. Methods Between January 2013 and December 2014, 105 cases of patients with diabetic peripheral neuropathy were randomly divided into treatment group （ n=53 ） and the control group （ n=52 ） . The control group were combined with high blood pressure, the treatment group used the basic treatment plus warfarin with oral drop of Vitamin B1 cobalt ammonium. The control group was given the basic treatment plus oral drops of aspirin and vitamin B1 cobalt ammonium, three months for a period of treatment, and chnical result was observed. Results The median nerve and common peroneal nerve of the sensory nerve conduction velocity （ SNCV ） ; The median nerve and common peroneal nerve of motor nerve conduction velocity （MNCV） in the observation group were higher （P〈0.05） ; 30 cases in the treatment group were markedly effective, improvement in 17 cases, 6 no effect, the total effective rate was 88%. 15 cases of control group were effective, 10 cases were markedly improved, 27 cases no effect, total effective rate was 48%. Statistically significant was found in the two groups （ P〈0.05 ） . Coaclusion There is markedly effective of giving priority to warfarin to treat type 2 diabetes peripheral neuropathy.