性别及年龄对健康人群糖化血红蛋白水平的影响

Effect of gender and age on HbA1c levels in healthy people

目的研究成都地区健康人群糖化血红蛋白(glycosylated hemoglobin,Hb A1c)水平与性别、年龄的关系。方法纳入2009-2016年共41 795例健康人群为研究对象,分析Hb A1c水平与年龄、性别的关系。结果健康人群Hb A1c水平随年龄的增长呈逐渐增高的趋势;男性青年组、中年组、老年组Hb A1c水平分别为5.43%±0.58%、5.75%±0.89%、6.07%±0.98%,组间比较差异有统计学意义(P<0.01)。女性青年组、中年组、老年组Hb A1c水平分别为5.23%±0.36%、5.56%±0.65%、6.04%±0.93%,组间比较差异有统计学意义(P均<0.01);男性≤30岁、31~40岁、41~50岁、51~65岁、>65岁年龄段Hb A1c水平分别为5.32%±0.46%、5.46%±0.61%、5.64%±0.78%、5.88%±0.97%、6.04%±0.99%,女性Hb A1c水平分别为5.21%±0.36%、5.23%±0.36%、5.41%±0.54%、5.71%±0.67%、5.98%±0.92%,相同年龄段男性与女性Hb A1c水平组间比较差异有统计学意义(P均<0.05)。结论健康人群Hb A1c水平随年龄的增长呈逐渐增高的趋势,同时存在性别差异,建议对不同性别及不同年龄段人群设置参考值。

Objective To study the effect of gender and age on glycosylated hemoglobin level in healthy people in Chengdu. Methods A total of 41 795 healthy people were recruited in our study from 2009 to 2016. The average HbAlc levels of the healthy people were compared between different age groups and gender. Results The HbAlc levels increased with age in healthy people. The HbAlc levels in young, middle-aged and older group were 5.43% ± 0.58%, 5.75% ±0.89%, 6.07% ± 0.98%, respectively in male, and 5.23% ± 0.36%, 5.56% ± 0.65%, 6.04% ± 0.93% respectively in female with statistically significant differences between age groups （AllP 〈 0.01）. The HbAlc levels were 5.32% ± 0.46%, 5.46% ±0.61%, 5.64% ± 0.78%, 5.88% ± 0.97%, 6.04% ± 0.99% respectively in ≤ 30 years, 31-40 years, 41-50 years, 51-65 years, 〉 65 years male groups, and 5.21% ± 0.36%, 5.23% ±0.36%, 5.41%± 0.54%, 5.71% ±0.67%, 5.98% ±0.92% respectively in ≤ 30 years, 31-40 years, 41-50 years, 51-65 years, 〉 65 years female groups. The differences in HbAlc levels between male and female were statistically significant in all age groups （All P 〈 0.05）. Conclusion The HbAlc level shows a gradual increasing trend with age, and it is higher in male compared with female in healthy people. We advise that the different reference value should be set by gender and age groups.