白藜芦醇抑制小胶质细胞激活在神经炎症中的研究进展

Research Progress of Resveratrol Inhibiting Microglial Activation in Neuroinflammation

神经炎症与诸多神经退行性疾病密切相关,小胶质细胞(microglia,MG)是重要参与者之一,其在生理病理状态下均发挥重要作用。因此,抑制MG的过度激活是控制神经炎症潜在的药物靶点。近年研究发现白藜芦醇(resveratrol,Res)对神经退行性疾病的保护作用与其抑制MG激活调控神经炎症有关,笔者对其可能的机制进行综述。

Many neurodegenerative diseases are closely linked with neuroinflammation, microglia is one of the important partici- pants, which plays an important role in physiological and pathological states. Therefore, inhibiting the excessive activation of microglia will be the potential drug targets of control neuroinflammation. Recent studies have found resveratrol in the central nervous system have a neuroprotective effect, which related to the inhibition of microglia activation and control of neuroinflammation. In this study, its pos- sible mechanisms will be reviewed.