三联序贯疗法治疗慢性非特异性溃疡性结肠炎疗效观察

Observation of Clinical Therapeutic Effect on Chronic Non-specific Ulcerative Colitis Treated by Triple Sequential Therapy

目的:观察三联序贯疗法治疗慢性非特异性溃疡性结肠炎的临床疗效。方法:80例随机分为观察组和对照组各40例,对照组用美莎拉嗪治疗,观察组用三联序贯疗法治疗,4周为一疗程。结果:治疗4周后,两组腹痛、里急后重和腹泻症状较治疗前明显减轻(P<0.05),观察组症状缓解效果优于对照组(P<0.05);观察组血清TNF-α、IL-6、IL-8水平低于对照组(P<0.05),总有效率观察组高于对照组(P<0.05)。结论:三联序贯疗法治疗慢性非特异性溃疡性结肠炎临床疗效显著。

Objective： To study the clinical therapeutic effect of triple sequential therapy in the treatment of chronic nonspecific ulcerative colitis. Method： A total of 80 patients with chronic non-specific ulcerative colitis were divided into observation group and control group in random, 40 cases in each group. The control group were treated with melamine while the observation group were treated with triple sequential therapy,4 weeks as 1 course of treatment. Result： After 4 weeks of treatment, the symptoms of abdominal pain, tenesmus and diarrhea of both groups were significantly relieved than that before the treatment （ P 〈 0.05 ） . The relieve effect of the observation group was superior to that of the control group. The level of TNF- ot, IL-6 and IL in the observation group was significantly lower than that in the control group （ P 〈 0.05 ） .The difference was statistically significant （ P 〈 0.05 ） . The total effective rate of the observation group was significantly higher than that of the control group （P 〈 0.05 ） .Conclusion： Triple sequential therapy has significant clinical therapeutic effect on chronic non-specific ulcerative colitis.