婴儿面部血管瘤中PHACE综合征发生率及其与血管瘤面积的相关性

The Incidence of PHACE Syndrome in Infantile Facial Hemangioma and its Correlation with Hemangioma Area

目的了解婴儿面部血管瘤中PHACE综合征发生率及其与血管瘤面积的相关性。方法对2014年3月-2015年12月本院诊治的2 478例面部婴儿血管瘤进行筛查,对血管瘤面积>5cm2且长径>5cm者行颅内核磁共振成像(MRI)、心脏及主动脉超声和眼底镜检查。结果 2 478例患者中符合面部血管瘤面积>5cm2且长径>5cm共93例,确诊PHACE综合征20例(21.51%)。面部血管瘤面积与PHACE综合征发生率呈显著正相关(r=0.316,P=0.035),单因素Logistic回归分析显示面部血管瘤面积是PHACE综合征的危险因素。结论 PHACE综合征在面部血管瘤面积较大的婴儿中发生率较高,对可疑患儿建议采用MRI颅内平扫和颅内血管核磁成像;婴儿面部血管瘤面积增大,PHACE综合征患病风险增高。

Objective To investigate the incidence of PHACE syndrome in infantile facial hemangioma and its correlation with hemangioma area.Methods From March 2014 to December 2015, our hospital diagnosed 2 478 patients with facial hemangiomas.Moreover,Patients with hemangioma area〉 5cm2 and diameter〉 5cm were examined by intracranial magnetic resonance imaging（MRI）,heart and aortic ultrasonography,ophthalmoscopy.Results Among the 2 478 patients,93 cases met facial hemangiomas which were area〉5cm2 and long diameter〉5cm,20 cases（21.51%）were confirmed PHACE syndrome.There was a significant positive correlation between the area of facial hemangioma and the incidence of PHACE syndrome（r=0.316, P=0.035）.Univariate logistic regression analysis showed that the area of facial hemangioma was a risk factor for PHACE syndrome.Conclusion PHACE syndrome in large area of facial hemangioma patients with higher incidence, we recommend the use of Magnetic Resonance Imaging and Magnetic Resonance Angiography for suspected children.The greater the area of facial hemangioma is, the higher the incidence of PHACE syndrome is.