树突状细胞在银屑病发病中的作用

Role of Dendritic Cells in the Pathogenesis of Psoriasis

树突状细胞(dendritic cells,DCs)是一种抗原呈递细胞,广泛分布于组织及器官中。在皮肤中DCs主要包括朗格汉斯细胞(Langerhans cells,LCs)、浆细胞样树突状细胞(plasmacytoid dendritic cells,pDCs)及髓样树突状细胞(myeloid dendritic cells,mDCs)三种亚型。近年来随着对银屑病发病机制研究的深入,DCs在银屑病中的作用被大家所关注。pDCs在抗原刺激或应激下,通过分泌IFN-α启动银屑病;mDCs在抗原及IFN-α作用下成熟并迁移至淋巴结,通过抗原提呈及所分泌的细胞因子,促进T细胞增殖、分化及迁移,参与银屑病的进展。

DCs are antigen presenting cells, which are widely distributed in tissues and organs.In the skin, DCs mainly includes LCs, pDCs and mDCs.In recent years, with the indepth study of the pathogenesis of psoriasis, the role of DCs in psoriasis is widely concerned.PDCs start psoriasis through the secretion of IFN-α,under the antigenic stimulation or stress status; under the action of antigen and IFN-α, mDCs mature and migrate to the lymph nodes, and through antigen presentation and cytokine secretion to promote T cell proliferation, differentiation, migration and finally aggravate psoriasis.