宫颈癌患者性功能、抑郁及生活质量调查分析

Survey on Sexual Function, Depression and Quality of Life in Patients with Cervical Cancer

【目的】分析宫颈癌患者性功能、抑郁水平和生活质量现状及其相关性。【方法】选择2016年6月至2017年6月本院收治的137例宫颈癌患者进行调查问卷。采用女性性功能指数（FSFI）量表评估患者性功能、医院焦虑和抑郁自评量表抑郁（HADS-D）评估患者抑郁情况，癌症治疗功能评定量表（FACT—G）评估患者生活质量，分析宫颈癌患者性功能、抑郁及生活质量影响因素，并采用Pearson相关性分析宫颈癌患者性功能、抑郁和生活质量的相关性。【结果】本组宫颈癌患者性功能评分为（4．83±1．16）分，抑郁评分（11．08±5．06）分，生活质量评分为（57．33士8．47）分。其中31患者（22．63％）未发生抑郁，46例患者（33．57％）发生轻度抑郁，60例患者（43．79％）发生中度及以上抑郁。年龄20～39岁者性功能、生活质量评分显著高于其他年龄段；大学以下文化程度者性功能评分显著高于大学文化程度者；就业者性功能评分高于未就业者，抑郁评分低于未就业者；主要照料人为父母者性功能评分高于子女、配偶及其他照料人者；化疗药物为5-氟尿嘧啶＋顺铂者性功能评分高于其他化疗药物者，差异均具有统计学意义（P〈0．05）。Pearson相关性分析结果显示，宫颈癌患者性功能与抑郁呈显著负相关（r=-0．408，P〈0．001），与生活质量呈显著正相关（r=0．303，P〈0．001）。【结论】性功能评分较低的宫颈癌患者生活质量较低，其抑郁症严重程度较高，对其应给予积极地干预，以改善患者生活质量。

[Objective]To survey on the status of sexual function, depression and quality of life in patients with cervical cancer and investigate the relationship among those situations . [Methods]A total of 137 women, who were diagnosed as cervical cancer in our hospital from June 2016 to June 2017, completed the questionnaire survey. Sexual function was evaluated by the Female Sexual Function Index （FSFI）, depression was assessed by the Hospital Anxiety and Depression Scale （ HADS）, and the quality of life by the Functional Assessment of Cancer Therapy-Genera/ version 4 （FACT-G）. Descriptive statistics, ANOVA, Scheffe＇s tests, and Pearson correlations were computed with software SPSS Win 21.0. [Results] The average scores of sexual function depression and the quality of life in the participants of this study were 4.83 ± 1.16, 11.08 ± 5.06 and 57.33 ± 8.47, respectively. Among them, 31 patients （22.63% ） had no depression, 46 patients （33.57 % ） had mild depression, and 60 patients （43.79 %） had moderate to severe depression. The scores of sexual function and quality of life in patients of ages 20~39 were significantly higher than those of other age groups. The score of sexual function in patients below college education were significantly higher than those of patients with college education. Patients with employment had higher sexual function scores than those of non-employment patients. The score of sexual function of patients whose main caregivers were parents were higher than those whose main earegivers were their children, spouses and other caregivers. The scores of sexual rune tion of patients with 5-fluorouracil plus cisplatin were higher than those of other chemotherapeutic drugs; the differ ences were statistically significant （ P 〈0.05）. Pearson correlation analysis showed that there was a significant nega rive correlation between sexual function and depression （ r = -0.408, P 〈0.001）, and a significant positively correlated with quality of life （ r =0.g03, P 〈0.001） in patients with cervical cancer. In addition, the survey showed sexual function was positively correlated with physical well-being, social well-being, and functional well-being（P =0.001）, but not with psychological well-being （ P =0.223）. [ConclusionlThis study reveals cervical cancer patients with lower sexual function tended to have lower quality of life and higher severity of depression, which should be ac- tively intervened to improve the quality of life of those patients.