IL-6和Shh在种植体周围炎龈沟液中的表达及意义被引量：9

Expression of IL-6 and Shh in Gingival Crevicular Fluid of Patients with Peri-implantitis

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摘要目的:研究种植修复患者龈沟液中的IL-6和Shh的水平与种植体周围炎的关系及其意义。方法:根据25例种植体修复患者的种植体周围组织情况将其分为种植体健康组(10例)和种植体周围炎组(15例)。采用酶联免疫吸附试验(ELISA法)检测IL-6和Shh在种植体周围炎龈沟液和正常种植体周围龈沟液中的浓度。结果:IL-6和Shh在种植体周围炎组中的表达显著高于种植体健康组,且差异具有统计学意义(P<0.001)。IL-6与Shh无相关性(P>0.05)。结论:种植体周围龈沟液中IL-6和Shh浓度的升高可以较好地反映种植体周围组织的健康状态。Shh有可能成为评价种植体周围炎进展的生物标记物。 Objective：To study the expression of IL-6 and Shh in patients with peri-implantitis.Methods：Twenty-five patients were included and divided into health implant group（10 cases）and peri-implantitis group（15 cases）.The expressions of IL-6 and Shh in health implant group and peri-implantitis group were detected by ELISA assay.Results：The expressions of IL-6 and Shh in the peri-implantitis group were significantly higher than those in the health implant group（P〈0.001）.There was no positive correlation between IL-6 and Shh（P〈0.05）.Conclusion：IL-6 and Shh were increased in gingival crevicular fluid of patients with peri-implantitis,and Shh might be a marker to determine the progress of peri-implantitis.

作者程志芬崔连保玄延花

机构地区郑州大学第一附属医院郑州大学口腔医学院山东济南雅宝特口腔门诊延边大学医学院病理学教研部

出处《口腔医学研究》 CAS 北大核心 2018年第1期87-89,共3页 Journal of Oral Science Research

基金吉林省教育厅"十三五"科学技术研究项目(编号:吉教科合字[2016]第266号)

关键词 IL-6 SHH 种植体周围炎龈沟液 IL-6 Shh Peri--implantitis Gingival crevicular fluid

分类号 R782.1 [医药卫生—口腔医学]

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