1878例前臂尺桡骨远端骨密度与颈动脉粥样硬化的相关分析

Correlational analysis between bone mineral density of the distal ulna and radius and carotid atherosclerosis in 1878 cases

目的探讨骨密度与颈动脉粥样硬化之间的关系。方法选自2013年1月至2016年6月,在我院进行前臂骨密度测量和同时做彩色多普勒颈动脉超声检查的体检人群,共计1878例。根据颈动脉内中膜厚度(intima-media thickness,IMT)超声诊断标准:分为动脉正常组587例,男性330例、女性257例;动脉硬化组1291例,男性912例、女性379例。年龄20~92岁,平均年龄52岁,其中男性53岁,女性49岁。按性别、每十岁年龄段一组,分别计算每一年龄段两组间骨密度进行统计学分析。利用SPSS19.0统计软件对数据进行处理分析,计量资料采用x珋±s方式表示,两组之间进行独立样本T检验,P<0.05为差异有统计学意义。结果动脉正常组与动脉硬化组男、女性峰值骨量均出现在30至40岁之间;女性峰值骨量明显低于男性;50岁后女性骨量丢失高于男性;动脉硬化于40岁后明显增加,男性高于女性;男女动脉硬化组与颈动脉正常组之间骨密度值高、低比较均无统计学意义,P>0.05。结论动脉硬化与骨质疏松症是与年龄相关的疾病,发病率都随年龄的增长而增加,两者彼此之间的作用机制和发病机理还需深入研究。

Objective To investigate the relationship between bone mineral density（BMD） and carotid atherosclerosis.Methods A total of 1878 cases received BMD measurement for the forearm and simultaneous color Doppler carotid ultrasound examination in our hospital from January 2013 to June 2016.According to the diagnostic criteria of carotid intima-media thickness（IMT）,there were 587 cases in arterial normal group（330 males and 257 females） and 1291 cases in arteriosclerosis group（912 males and 379 females）.The age was from 20 to 92 years old,with the mean age of 52 years old（53 years in males and 49 years in females）.They were divided into groups according to gender and every 10-year division.BMD in each age group was calculated and analyzed.SPSS19.0 statistical software was used to analyze the data.The numbered data were expressed as x± s,and the independent sample T test was performed between the two groups.P〈0.05 was considered statistically significant.Results The peak bone mass of both the male and female occurred between 30 and 40 years old in arterial normal group and atherosclerosis group.The peak bone mass of females was lower than that of males.The bone loss in females was higher than that in males after 50 years old.Carotid atherosclerosis increased after 40 years old,and it was more obvious in males than in females.There was no significant difference of BMD between the male and female arterial normal group and arteriosclerosis group（P〉0.05）.Conclusion Arteriosclerosis and osteoporosis are age-related diseases.The incidence increases with age.The mechanism and pathogenesis between the two need to be studied in depth.