不同时机营养干预在化疗后Ⅳ度骨髓抑制肿瘤患者中的疗效比较

Comparison of Different Time Nutritional Intervention on Chemotherapy-induced Ⅳ Degree Myelosuppression in Cancer Patients

目的回顾性分析探讨并比较不同时机营养治疗在化疗后Ⅳ度骨髓抑制肿瘤患者中的优劣性。方法回顾性分析两组(早期营养干预组和晚期营养干预组)化疗后Ⅳ度骨髓抑制的患者,比较两组患者在粒细胞、血小板等上升时间,合并细菌、真菌感染的比例,死亡率等的差异。结果早期干预组在白细胞、血小板等开始上升时间(4.8±1.8)、(7.6±2.2)早于晚期营养干预组(7.2±2.5)、(12.2±3.1),且早期营养干预组细菌、真菌感染发生率及死亡率(17.10%、9.21%、3.94%)等亦低于晚期营养干预组(42.85%、26.98%、12.70%)。结论早期积极营养支持不仅有利于缩短白细胞等恢复时间,而且可以减少感染的发生率、死亡率等。

Objective To explore and evaluate the effect of different time nutrition intervention on chemotherapy-induced IV degree myelosuppression in cancer patients. Methods A retrospective analysis was conducted on two groups of caner patients with chemotherapy-induced IV degree myelosuppression. The early nutritional intervention group： patients received nutritional intervention within 72 hours after diagnosis of IV degree myelosuppression; in contrast, the other group was set as the late nutrition intervention group. We investigated and compared the difference between the two groups in the rising time of leukocyte and platelet, bacterial infection rates, fungal infection rates and mortality rates. Results In the early nutritional intervention group, the rising time of leukocyte and platelet （（4,8±1.8） and （7.6±2.2）） was earlier than those in the late nutritional intervention group（（7.2±2.5） and （12.2±3.1））; in addition, the early nutritional support group sustained significantly fewer incidence of bacterial infection, fungal infection and mortality（17.10%, 9.21% and 3,94%） than those in the late nutritional intervention group （42.85%, 26.98% and 12.70%）. Conclusion The early nutritional intervention could reduce the recovery time of leukocyte and platelet, bacterial infection rates, fungal infection rates and mortality rates.