不同剂型米诺环素治疗慢性牙周炎临床效果评价

Evaluation of the clinical efficacy in the treatment of minocycline in different dosage forms of chronic periodontitis

目的通过评价米诺环素不同剂型的临床疗效，为慢性牙周炎的合理用药提供依据。方法本实验筛选慢性牙周炎患者26例，患牙79颗，随机分为软膏组38颗和凝胶组41颗。对所有患牙进行牙周洁刮治疗，术后1周复诊，测菌斑指数（PLI）、龈沟出血指数（SBI）、牙周袋深度（PD）和附着丧失（AL）四项指标并设为基线，取米诺环素软膏或凝胶置于患者牙周袋内，分别与术后6周、12周复诊，测定四项指标。结果术后1周基线时软膏组和凝胶组四项指标差异无统计学意义（P〉0．05）。给药后PLI、SBI、PD值明显下降，软膏组明显优于凝胶组（P〈0．05）。2组的AL值无明显变化（P〉0．05）。结论米诺环素对慢性牙周炎的临床指数有明显改善，米诺环素软膏预后优于凝胶剂型。

Objective To evaluate clinical efficacy of minocycline in different dosage forms in the treatment of chro- nic periodontitis, so as to provide evidence for rational treatment of chronic periodontitis. Methods A total of 26 chronic periodontitis patients with 79 diseased teeth were enrolled in the current study. They were randomly divided into an oint- ment group and a gel group. All patients first underwent sealing and root planning followed by administration of minocy- cline ointment or gel in the periodontal pocket. The clinical effects were assess based on plaque index （PLI） , sulcus bleeding index （SBI）, probing depth （PD） and attachment loss （AL） at baseline, and six and twelve weeks after sur- gery. Results There was no statistically significant difference in the above baseline indexes between the ointment group and the gel group （P 〉 0.05 ）. After administration, remarkable decreases were found in PLI, SBI and PD in the oint- ment group, compared with those in the gel group （P 〈 0.05 ）. No statistical difference was found in AI between the both groups （P 〉 0.05 ）. Conclusions Administration with minocyeline can markedly improve the clinical idexes of chronic periodontitis, where better prognosis is found after ointment use than gel use.