康复新液辅助生长抑素治疗非甾体药物致上消化道出血临床疗效及安全性研究

Curative efficacy and safety of Kangfuxin liquid in treating patients of upper gastrointestinal hemorrhage caused by non-steroid drugs treated with somatostatin

目的:探讨康复新液辅助生长抑素治疗非甾体药物致上消化道出血的临床疗效及安全性。方法:收集90例符合纳入标准的非甾体药物致上消化道出血患者作为观察对象,随机分为对照组45例和观察组45例。常规治疗基础上,对照组给予生长抑素治疗。观察组在对照组基础上给予康复新液辅助治疗。比较两组患者临床疗效、止血时间、再出血率、血清炎性因子水平及不良反应。结果:临床疗效显示,观察组患者治疗总有效率高于对照组(95.6%vs 82.2%),组间比较有统计学差异(P<0.05)。与对照组相比,观察组的止血时间明显缩短[(1.4±0.5)d vs(2.6±0.7)d,P<0.05],而再出血率组间比较无统计学差异(4.4%vs 11.1%,P>0.05)。治疗后,观察组患者血清TNF-α、IL-6水平降低[(5.46±0.93)ng/L vs(8.37±1.08)ng/L,(19.37±3.43)ng/L vs(38.22±8.14)ng/L],组间比较都有统计学差异(P<0.05)。治疗过程中,无严重不良反应病例。观察组和对照组患者不良反应发生率分别为22.2%和15.6%,组间比较无统计学差异(P>0.05)。结论:康复新液辅助生长抑素在非甾体药物致上消化道出血中应用效果良好,能够提高治疗有效率,缩短止血时间,减轻炎性反应,且不良反应轻微,临床上值得应用。

Objective： To investigate the curative efficacy and safety of Kangfuxin liquid in treating patients of upper gastrointestinal hemorrhage caused by non-steroid drugs treated with somatostatin. Methods： 90 patients with upper gastrointestinal hemorrhage caused by non-steroid drugs meeting the inclusion criteria were collected as observational objects to be randomly divided into the control group and the observation group with 45 cases in each group. Besides conventional treatments,the control group was given somatostatin,while the observation group was given Kangfuxin liquid in combination with somatostatin. Then,the curative efficiency,hemostatic time,recurrent bleeding rate,levels of serum inflammatory factors and adverse reactions were observed and compared. Results： Assessment of curative efficacy showed that the total therapeutic efficiency ratio in the observation group was statistically higher than that in the control group（ 95. 6% vs 82. 2%,P〈0. 05）. In comparison with the control group,the hemostatic time in the observation group was statistically shorter[（ 1. 4±0. 5） d vs（ 2. 6±0. 7） d,P〈0. 05],while the recurrent bleeding rate in the two groups was statistically same（ 4. 4% vs11. 1%,P〈0. 05）. As to inflammatory factors,the observation group had statistically lower levels of serum TNF-α and IL-6 than those in the control group[（ 5. 46±0. 93） ng/L vs（ 8. 37±1. 08） ng/L,（ 19. 37±3. 43） ng/L vs（ 38. 22±8. 14） ng/L,both P〈0. 05]. During the treatment,there was no case of severe adverse reactions. And the incidences of adverse reactions in the observation group and the control group were statistically same（ 22. 2% vs 15. 6%,P〈0. 05）. Conclusion： Besides treatment of somatostatin,adjuvant therapy of Kangfuxin liquid has well application effect in patients of upper gastrointestinal hemorrhage caused by non-steroid drugs. And it can significantly increase curative efficacy,shorten hemostatic time,alleviate inflammatory reaction with minor adverse reactions.