NLRP3炎症小体在狼疮性肾炎中作用的研究进展

Research progress of role of NLRP3 inflammasome in lupus nephritis

系统性红斑狼疮(SLE)是一种自身免疫性疾病,其发病机制极为复杂,随着研究的深入,炎症小体在狼疮性肾炎(LN)的发病中作用也逐渐受到重视。其中,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体是目前研究最详尽的一类炎症体。我们对近年来NLRP3炎症小体在LN中作用的相关研究进行归纳总结,发现NLRP3炎症小体不仅在LN的发病中起着重要的作用,并通过循环免疫细胞和固有细胞参与肾脏损伤的过程。最后介绍了两种NLRP3炎症小体的特异性抑制剂β-羟基丁酸酯和MCC950,为LN治疗提供了新的策略。

Systemic lupus erythematosus（ SLE） is an autoimmune disease whose pathogenesis is extremely complicated. With the further research,the role of inflammasome in the pathogenesis of Lupus nephritis has also been gradually emphasized. Among them,the nucleotide-binding oligomerization domain-like receptors family pyrin domain containing 3（ NLRP3） inflammasome is the most exhaustive inflammasome. We summarize the related studies on the role of NLRP3 inflammasome in Lupus nephritis in recent years. We found that NLRP3 inflammasome not only plays an important role in the pathogenesis of Lupus nephritis,but also participates in the process of kidney injury by circulating immune cells and renal innate cells. Finally,we introduced two specific inhibitors of NLRP3 inflammasome,β-hydroxybutyrate and MCC950,which provided a new strategy for the treatment of Lupus nephritis.