以胃泌素为靶点治疗肿瘤药物的研究进展

Research progress of gastrins-targeted antineoplastic drugs

胃泌素为一类胃肠道激素,正常情况下通过结合相应受体发挥促进胃酸分泌与胃肠道粘膜生长作用。近来越来越多的研究表明:过量表达的胃泌素可通过自分泌、旁分泌或内分泌方式,导致多种消化系肿瘤(包括胃癌、肠癌、胰腺癌、食管癌等)的发生发展。因而,胃泌素分子目前已成为治疗相关肿瘤的靶点。本文围绕以胃泌素为靶点治疗肿瘤药物(包括分泌抑制剂、受体拮抗剂与抗胃泌素抗体)的研究进展进行综述,以期为研究者进行后续研究与开发提供参考。

Gastrins are gastrointestinal hormones,which can promote the secretion of gastric acid and the growth of gastrointestinal mucosa by binding corresponding receptors in normal conditions.Recently numerous studies have shown that the over-expression of gastrins could promote digestive tumors such as gastric,colon,pancreatic and esophageal cancers by autocrine,paracrine or endocrine way,which has also warranted the gastrins as preferred anti-tumor target in cancers expressing the stimulatory factor.This article focuses on the current research progress of gastrins-targeted antineoplastic drugs including secretion inhibitors,receptor antagonists and anti-gastrin antibody to provide a reference for related study or development.