单核细胞趋化蛋白-1与慢性肝病及并其发症的相关性

Relationship of MCP-1, chronic hepatic disease and its complications

持续的肝脏炎症是慢性肝脏疾病进展的一个重要因素,趋化因子通过调节肝细胞、库普弗细胞、肝星状细胞、内皮细胞和循环免疫细胞的活动和迁移,在肝脏炎症的发生和发展中起着重要作用。单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)属于CC趋化因子家族,在机体发生炎症反应和组织损伤时发挥激活、招募、迁移单核-巨噬细胞、中性粒细胞和淋巴细胞的功能。MCP-1对慢性乙型肝炎、慢性丙型肝炎、非酒精性脂肪性肝病、自身免疫性肝病、肝纤维化和肝硬化自发性细菌性腹膜炎等的发生、发展及预后有重要影响。本文对近几年MCP-1与慢性肝病及并发症相关性的进展进行综述。

Sustained hepatic infammation is an important factor in developing and progression of chronic liver diseases. Chemokines play important roles through regulating the activities, migration, recruitment of hepatocytes, Kupffer cells, hepatic stellate cells, endothelial cells and circulating immune cells. Monocyte chemoattractant protein 1 （MCP-1） belongs to CC chemokine family, exerts enormous functions in activities and migration, recruitment of mononeuclear phagocyte, neutrophil, lymphocyte in inflammatory response and tissue damage. MCP-1 has effect on developing and progression of chronic hepatisis B, chronic hepatisis C, nonalcoholic fatty liver disease, hepatic fbrosis and spontaneous bacterial peritonitis in hepatic cirrhosis. This article reviewed the research progress of related relationship of MCP-1, chronic liver diseases and its complications in recent years.