新辅助放化疗在局部进展期直肠癌中近期临床运用观察

Clinical Application of Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer

目的观察新辅助放化疗在局部进展期直肠癌中的临床效果。方法随机选取我院2010年1月—2013年1月收治的34例局部进展期直肠癌患者进行随机分组,分为对照组与观察组,每组各17例。对照组采用传统手术方式进行治疗,观察组通过三维适形进行放疗同时口服卡培他滨进行新辅助放化疗,放化疗结束后6~8周进行手术。观察并对比两组治疗效果、局部复发情况。结果观察组患者治疗效果、局部复发等情况优于对照组,且差异具有统计学意义,P<0.05。结论应用三维适形放疗,口服卡培他滨进行新辅助放化疗方式进行治疗具有效果良好、显著提高保肛率、局部复发率低等特点。

Objective To observe the clinical effect of neoadjuvant chemotherapy in locally advanced rectal cancer. Methods 34 patients with locally advanced rectal cancer in our hospital from January 2010 to January 2013 were randomly divided into control group and observation group, 17 cases in each group. The control group was treated by traditional operation, the observation group was treated by three-dimensional conformal radiotherapy and oral capecitabine for neoadjuvant radiotherapy and chemotherapy, and the surgery was performed 6 to 8 weeks after radiotherapy and chemotherapy. The therapeutic effect and local recurrence of the two groups were observed and compared.Results The treatment effect and local recurrence of patients in observation group were better than those in control group, and the difference was significant( P < 0.05). Conclusion Three-dimensional conformal radiotherapy, oral capecitabine for neoadjuvant radiotherapy and chemotherapy has a good effect, significantly improve anal retention rate, local recurrence rate is low and so on.