银杏叶提取物对腔隙性脑梗死后脑血管内径及炎性反应物的影响

Effect of Ginkgo Biloba Extract on Lacunar Infarction and Cerebral Vascular Diameter and Inflammatory Reaction

目的探讨银杏叶提取物对腔隙性脑梗死后脑血管内径及炎性反应物的影响。方法选取我院2012年1月—2017年1月收治的124例腔隙性脑梗死患者为研究对象,将所有患者随机分为观察组与对照组,每组62例,对照组给予调整血压、抗凝、神经细胞活化剂、活血化瘀等常规治疗,观察组在常规治疗的基础上再给予银杏叶提取物治疗,对比两组患者临床疗效、治疗前后平均血流速度和颈椎动脉口径以及血清超敏C-反应蛋白(hs-CRP)水平。结果观察组临床治疗有效率(90.32%)高于对照组(38.71%),差异具有统计学意义(P<0.05)。治疗前两组患者平均血流速度和颈椎动脉口径对比差异无统计学意义(P>0.05);治疗后观察组平均血流速度和颈椎动脉口径均优于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者血清hs-CRP水平对比差异无统计学意义(P>0.05);治疗后观察组血清hs-CRP水平低于对照组,差异具有统计学意义(P<0.05)。结论银杏叶提取物对腔隙性脑梗死后脑血管内径及炎性反应物具有积极的影响,临床效果满意。

Objective To investigate the effects of Ginkgo biloba extract on lacunar infarction and cerebral vascular diameter and inflammatory reaction. Methods In our hospital, 124 cases of patients with lacunar infarction were studied from January 2012 to January 2017. All patients were randomly divided into observation group and control group, 62 cases in each group, the control group was given to adjust blood pressure, anticoagulation, nerve cell activator, blood circulation and other conventional treatment, the observation group based on routine treatment combined with Ginkgo biloba extract before and after treatment. The clinical efficacy of the two groups, the average velocity of blood flow before and after treatment and the caliber of the cervical artery and the level of serum hypersensitivity Creaction protein(hs-CRP) were compared. Results The effective rate of clinical treatment in the observation group was 90.32%, significantly higher than that of the control group of 38.71%, and the difference was statistically significant(P < 0.05). Before treatment, there was no significant difference in mean blood flow velocity and cervical artery caliber between the two groups(P > 0.05). After treatment, the average blood flow velocity and the diameter of the cervical artery in the observation group were significantly better than those in the control group, the difference was statistically significant(P < 0.05). Before treatment, there was no significant difference in serum hs-CRP level between the two groups(P > 0.05). After treatment, the serum hs-CRP level in the observation group was significantly lower than that in the control group, the difference was statistically significant(P < 0.05). Conclusion Ginkgo biloba extract has a positive impact on lacunar infarction and cerebral vascular diameter and inflammatory reaction, the clinical effect is satisfactory.