microRNA在冠心病发生机制中的作用及其临床应用

Role of microRNA in the Mechanism of Coronary Heart Disease and Its Clinical Application

目的 探讨冠心病发生机制中microRNA的临床意义.方法 随机抽取赤峰市医院和北京阜外心血管病医院从2016年11月18日-2017年11月21日符合标准的208例冠心病患者为观察组,对照组取同期200例非冠心病患者.两组均予以microRNA检测.观察两组miR-155以及miR-146a指标.结果 观察组miR-155、miR-146a数据分别为（0.84±0.37）、（1.72±0.63）,相比对照组,差异均具有统计学意义（P 〈0.05）;在不同类型疾病中,稳定型心绞痛组miR-155最高,急性心肌梗死组最低;急性心肌梗死组miR-146a最高,稳定型心绞痛组最低,差异具有统计学意义（P 〈0.05）.结论 miR-155以及miR-146a表达与冠心病病情程度有一定关系,可为临床诊治提供依据.

Objective To investigate the clinical significance of microRNA in the mechanism of coronary heart disease. Methods A total of 208 patients with coronary heart disease who met the standard from November 18, 2016 to November 21, 2017 in the Chifeng Hospital and Beijing Fuwai Cardiovascular Hospital were randomly selected as the observation group. In the control group, 200 cases of non-coronary heart disease were taken at the same time. The two groups were tested by microRNA. The two groups of miR-155 and miR-146a were observed. Results The data of miR-155 and miR-146a in the observation group were （0.84 ± 0.37） and （1.72 ± 0.63） respectively. Compared with the control group, the difference was statistically significant （P 〈 0.05）. Among the different types of disease, miR-155 was the highest in the stable angina pectoris group and the lowest in the acute myocardial infarction group. The miR-146a was the highest in the acute myocardial infarction group and the lowest in the stable angina pectoris group, and the difference was statistically signifcant （P 〈 0.05）. Conclusion The expression of miR-155 and miR-146a has a certain relationship with the degree of coronary heart disease, which can provide a basis for clinical diagnosis and treatment.