卡培他滨联合奥沙利铂治疗进展期大肠癌疗效及预后效果

The Effect and Prognosis of Capecitabine Combined With Oxaliplatin in the Treatment of Advanced Colorectal Cancer

目的分析卡培他滨配合奥沙利铂对进展期大肠癌的化疗及预后效果。方法随机选取本院自2016年4月—2017年4月收治的进展期大肠癌患者50例作为研究对象。根据随机数字表法,将其分为对照组(25例)、治疗组(25例)。对照组采用常规治疗,治疗组采用卡培他滨配合奥沙利铂治疗,分析两组治疗有效率、不良反应发生率、血清指标。结果两组患者的治疗有效率对比,差异无统计学意义(P>0.05);治疗组患者的不良反应发生率低于对照组,差异具有统计学意义(P<0.05);治疗组血清指标优于对照组,差异具有统计学意义(P<0.05)。结论对进展期大肠癌患者应用卡培他滨配合奥沙利铂化疗治疗,临床治疗效果显著。

Objective To analyze the effect of capecitabine and oxaliplatin on the chemotherapy and prognosis of advanced colorectal cancer. Methods 50 patients with advanced colorectal cancer treated in our hospital from April 2016 to April 2017 were selected as the study subjects. According to the random digital table method, they were divided into the control group （25 cases） and the treatment group （25 cases）. The control group was treated with routine treatment. The treatment group was treated with capecitabine and oxaliplatin. The effciency of treatment, the incidence of adverse reactions and the serum indexes were analyzed in the two groups. Results There was no signifcant difference in the effective rate of treatment between the two groups （P 〉 0.05）. The incidence of adverse reactions in the treatment group was lower than that in the control group, and the difference was statistically signifcant （P 〈 0.05）. The serum index of the treatment group was better than that of the control group, and the difference was statistically significant （P 〈 0.05）. Conclusion The application of capecitabine combined with oxaliplatin chemotherapy in patients with advanced colorectal cancer has signifcant clinical effect.