基于“异病同治”理论的银杏叶提取物及其活性成分防治心脑血管疾病共同靶标分析

Common target analysis of Ginkgo biloba extract and its active ingredients for co-treatment of cardiovascular and cerebrovascular diseases based on “same treatment for different diseases” theory

国内外的研究学者对银杏叶提取物及其活性成分的药理活性做了大量的调查研究,初步证实了其在防治心脑血管疾病方面的有效性。目前,心脑血管疾病相关性研究已经成为国际上高度关注的前沿领域之一。通过总结分析文献发现,银杏叶提取物及其活性成分前期研究对脑血管疾病的关注度高于心血管疾病,但缺乏对心脑血管疾病相关性和差异性研究的深度探讨。文章在此基础上,通过IPA(ingenuity pathway analysis)分析银杏叶提取物及其活性成分与心脑血管疾病共同靶标的相互作用关系,结果显示银杏叶提取物及其活性成分对心脑共同靶标可能包括动脉粥样硬化发展过程,提示它们可针对不同靶标或同一靶标来防治心脑血管疾病,这将为银杏叶提取物对心、脑血管疾病"异病同治"作用机制的研究提供新的研究方向。

Accumulating studies on the pharmacological activities of Ginkgo biloba extract（EGb） and its active ingredients have provided solid evidences on their roles in prevention and treatment of cardiovascular and cerebrovascular diseases.At present,correlation between cardiovascular and cerebrovascular diseases is becoming one of the most active research areas internationally.Literature search and analyses indicated that earlier investigations on EGb and its active ingredients focused on individual diseases with more attention paid to cerebrovascular disease than cardiovascular disease.Using the tool of IPA（ingenuity pathway analysis）,we have attempted to reanalyze the literature on Ginkgo biloba extract and its active components with a focus on the interaction between cardiovascular and cerebrovascular disease targets.The results showed that EGb and its active components had different effects on distinct heart and brain targets but their common targets include key molecules for the pathogenesis of atherosclerosis,suggesting that EGb and its active ingredients mayshare different or the same targets to prevent and treat cardiovascular and cerebrovascular diseases.Future in-depth investigation may shed new light on EGb and its active ingredients for the co-treatment of cardiovascular and cerebrovascular diseases based on ＂same treatment for different diseases＂ theory