中耳胆固醇肉芽肿与血脂代谢异常的相关性研究

Correlations Between Middle Ear Cholesterol Granuloma and Dyslipidemia

目的通过分析中耳胆固醇肉芽肿患者血脂代谢特点,探讨中耳胆固醇肉芽肿的发病机制与血脂代谢异常的关系。方法回顾收集近五年在我院就诊的57例中耳胆固醇肉芽肿患者血浆中的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)、载脂蛋白A1(APOA1)、载脂蛋白B(APOB)结果及其比值,同时以57例同期年龄和性别相匹配的,通过术后病理及影像学资料排除中耳胆固醇肉芽肿的慢性中耳炎患者的血脂水平作为对照,进行统计学分析。结果中耳胆固醇肉芽肿患者TC、LDL、APOA1及LDL/APOA1、APOB/APOA1水平较高于对照组,差异有统计学意义(P<0.05),两组间TG、HDL、APOB及HDL/APOB水平并无统计学差异(P>0.05),条件Logistic多因素分析显示TC、LDL是中耳胆固醇肉芽肿主要发病的危险因素。结论中耳胆固醇肉芽肿患者血脂水平高于非胆固醇肉芽肿患者,TC、LDL、APOA1及LDL/APOA1水平与中耳胆固醇肉芽肿的发病有相关性。

Objective To study the relationship between middle ear cholesterol granuloma and dyslipidemia by analyzing characteristics of lipid metabolism in patients with middle ear cholesterol granuloma. Methods Serum triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL), high density lipoprotein cholesterol(HDL), apolipoprotein A1(APOA1) and apolipoprotein B(APOB) contents in 57 cases of middle ear cholesterol granuloma were retrospectively analyze and compared to 57 age and gender matched cases of chronic otitis media without cholesterol granuloma(based on pathological and imaging diagnoses). Results TC, LDL, APOA1, LDL/APOA1, and APOB/APOA1 levels in cases of middle ear cholesterol granuloma were higher than in cases without cholesterol granuloma(P<0.05), but TG, HDL, APOB and HDL/APOB levels showed no difference between the two groups(P>0.05).Logistic multiple factors analysis showed that TC, LDL were risk factors for middle ear cholesterol granuloma. Conclusion Patients with middle ear cholesterol granuloma show higher lipid levels than patients without middle ear cholesterol granuloma, and TC, LDL, APOA1, LDL/APOA1 and APOB/APOA1 levels show correlation with the onset of middle ear cholesterol granuloma.