脂肪组织与骨质疏松相关性及机制的研究进展

The relationship between adipose tissue and osteoporosis and underlying mechanism

骨髓脂肪组织增加、微血管数目减少和微循环障碍是骨质疏松发生、发展的重要因素。而有关骨髓外脂肪组织与骨质疏松的相关性仍存在不同观点。髓外脂肪组织的分布在脂肪组织与骨的相互作用中尤为重要。不同部位的脂肪组织可分泌各种脂肪因子(瘦素、脂联素、生长素等)和炎症介质,影响骨质代谢。就不同部位脂肪组织的影像测量方法、脂肪组织与骨质疏松发生发展的相关性及相关作用机制予以综述。

Bone marrow adipose tissue increasing, microvessel reduction, and microcirculatory disturbance are im-portant factors of the genesis and progression of osteoporosis. However, there are still different opinions on the correlation be-tween extramedullary adipose tissue and osteoporosis. The distribution of extramedullary adipose tissue is especially impor-tant in the interaction between adipose tissue and bone. Adipose tissue can secrete various adipokines （leptin, adiponectin, ghrelin, etc.） and inflammatory mediators. Different parts of adipose tissue have different effects on bone. This paper mainly introduces the imaging methods for measuring different parts of adipose tissue, the correlation between adipose tissue and os-teoporosis and underlying mechanism.