大肠癌患者的血清糖链抗原125、糖链抗原19-9、癌胚抗原检测结果分析

Analysis of Serum CEA,CA125 and CA19-9 in Colorectal Carcinoma

目的探讨对大肠癌患者血清糖链抗原125(CA125)、糖链抗原19-9(CA19-9)、癌胚抗原(CEA)进行检测的结果与临床意义。方法选择256例大肠癌患者设为试验组,健康人256例设为对照组,两组均以化学光免疫法行CA125、CA19-9、CEA检测,观察对比两组检测结果。结果试验组CA125、CA19-9、CEA水平明显高于对照组(P<0.05);试验组CA125、CA19-9、CEA、三项指标联合阳性检出率均明显高于对照组(P<0.05);试验组不同分期患者CA125、CA19-9、CEA水平对比,C+D期明显高于A+B期(P<0.05);肿块型CA125、CA19-9阳性检出率明显高于溃疡型、浸润型,浸润型CEA阳性检出率明显高于其他两种类型(P<0.05)。结论在大肠癌患者中血清CA125、CA19-9、CEA检测灵敏度较高,可将其应用在大肠癌的诊断与分期中,以提升临床诊断准确度,为确定治疗方案提供依据,提升治疗效果。

Objective To investigate the clinical significance of serum CA125,CA19-9 and CEA in colorectal cancer patients.Methods 256 patients with colorectal cancer who were treated in our hospital were selected as the analysis group.256 patients were selected as the reference group.The two groups were treated with chemical immunoassay CA125 and CA19-9,CEA detection,observation than the two groups of test results.Results The levels of CA125,CA19-9 and CEA in the analysis group were significantly higher than those in the reference group.The positive rate of the three indexes was significantly higher than that of the control group,and the patients in the analysis group were different CA125,CA19-9,CEA level,C ＋ D period was significantly higher than A ＋ B stage,tumor CA125,CA19-9 positive detection rate was significantly higher than ulcer type,infiltration type,infiltration of CEA positive detection rate Significantly higher than the other two types（P0.05）.Conclusion In patients with colorectal cancer,serum CA125,CA19-9,CEA detection sensitivity is high,can be used in the diagnosis and staging of colorectal cancer,in order to improve the accuracy of clinical diagnosis,and for the treatment of the program to provide Basis,so that the effect of treatment to enhance.