低频重复经颅磁刺激辅助药物治疗老年脑梗死后焦虑抑郁患者的效果

The effect of RTMS assisted drug in treating anxiety and depression among elderly patients with cerebral infarction

目的观察低频重复经颅磁刺激(r TMS)辅助药物治疗老年急性脑梗死后焦虑、抑郁患者的临床效果。方法选取80例急性脑梗死后焦虑、抑郁老年患者,采用随机数字表法分为r TMS组和常规组各40例。两组均给予常规药物治疗,r TMS组同时加用r TMS治疗,疗程8周,对比两组患者的治疗效果。结果治疗后,r TMS组患者的汉密尔顿抑郁量表[(9.86±2.04)分]、汉密尔顿焦虑量表[(10.24±1.75)分]、中国脑卒中神经功能量表[(16.39±2.27)分]得分均低于常规组[(11.18±2.23)分、(12.05±2.11)分、(19.15±2.50)分],均差异有统计学意义(均P<0.05),r TMS组患者的血清脑源性神经营养因子[(28.14±4.42)μg·L-1·m L-1]高于常规组[(25.26±4.25)μg·L-1·m L-1],差异有统计学意义(P<0.05)。r TMS组患者的抑郁状态治疗总有效率92.50%、焦虑状态治疗总有效率92.50%,常规组为75.00%、72.50%,差异均有统计学意义(P<0.05)。结论 r TMS辅助药物治疗老年急性脑梗死后焦虑、抑郁患者有效。

Objective To investigate the clinical effect of low frequency repetitive transcranial magnetic stimulation( r TMS) in the treatment of anxiety and depression of elderly patients with acute cerebral infarction. Methods 80 cases of elderly patients with anxiety and depression after acute cerebral infarction were selected and randomly divided into r TMS group and the conventional group. The two groups were both given conventional drug therapy and r TMS group was added with r TMS treatment at the same time. After 8 weeks of treatment,the treatment effects of the two groups of patients were compared. Results After treatment,Hamilton Depression Scale [[( 9. 86 ± 2. 04) points],Hamilton Anxiety Scale [(10. 24 ± 1. 75) points]and Chinese brain stroke scale [16. 39 ± 2. 27) points]in r TMS group were lower than those in the conventional group [(11. 18 ± 2. 23) points,(12. 05 ± 2. 11) points and(19. 15 ± 2. 50)points,respectively],P < 0. 05. The serum level of brain-derived neurotrophic factor [( 28. 14 ± 4. 42) μg · L-1·m L-1)]in r TMS group was higher than that in the conventional group [(25. 26 ± 4. 25) μg·L-1·m L-1],P <0. 05. Conclusion RTMS assisted drug in the treatment of anxiety and depression in elderly patients with acute cerebral infarction has better effect than the single drug treatment.