肾俞穴激光照射辅助治疗系膜增生性肾小球肾炎的临床观察

Curative Effect Observation of Laser Therapy at Shenshu Point in Treating Mesangial Proliferative Glomerulonephritis

目的 观察激光照射肾俞穴对非肾病综合征的蛋白尿型系膜增生性肾小球肾炎（mesangial prolif-erative glomerulonephritis,MsPGN）患者蛋白尿和血管紧张素系统（renin-angiotonin-system,RAS）的影响.方法 60例非肾病综合征蛋白尿型MsPGN患者随机分为观察组和对照组,每组各30例.观察组在对照组治疗基础上行肾俞穴激光照射.观察治疗前后血浆肾素（Periplasmal Renin Activity PRA）、血管紧张素（Angioto-ninⅡAngⅡ）、24 h尿蛋白定量、尿微白蛋白、尿免疫球蛋白G（尿IgG）、尿 α1-微球蛋白（尿 α1-M）指标的变化.结果 与治疗前比,治疗后两组血浆24 h尿蛋白定量、尿微白蛋白、尿IgG、AngⅡ均明显下降（P〈0.05或P〈0.01）,尿 α1-M无明显变化（P〉0.05）;治疗后观察组24 h尿蛋白定量、尿微白蛋白、尿IgG、AngⅡ均较对照组低（P〈0.05或P〈0.01）.结论 激光照射肾俞穴可有效减少MsPGN患者肾小球性尿蛋白;降低血浆AngⅡ水平是其可能机制之一.

Objective To observe effects of laser therapy at shenshu point on proteinuria and rennin -angiotonin - system（RAS） in patients with mesangial proliferative glomerulonephritis （MsPGN）. Methods 60 patients with MsPGN were divided into observation group and control group with 30 patients in each group. Laser therapy at shenshu point was added to observation group. Periplasmal rennin activity （PRA） , angiotonin II , 24 hour urine protein, urine microalbumin, urine IgG, urine α1 -microglobulin were compared before and ＇after treatment. Results 24 hour urine protein, urine microalbumin,urine IgG and angiotensin II were significantly decreased in both groups after treatment （P 〈 0.01 or P 〈 0.05）. However, there was no significant difference in urine α1 -M in both groups after treatment （P 〉 0.05 ）. 24 hour urine protein, urine microalbumin, urine IgG and angiotensin II were significantly decreased in observation group than those in control group after therapy （ P 〈 0.01 or P 〈 0.05 ）. Conclusiort Laser therapy at shenshu point can efficiently decrease urine protein in patients with MsPGN. The decrease of plasma angiotensin II level may be one of the mechanisms.