氨酚氢可酮与羟考酮治疗急诊科中重度疼痛的效果对比研究

A comparative study on the effects of hydrocodone and oxycodone in the treatment of moderate to severe pain in the emergency department

目的对比分析氨酚氢可酮与羟考酮治疗急诊科中重度疼痛的有效性及安全性。方法选取急诊科95例出现中重度疼痛的患者,将其按随机数表法分为两组,对照组47例,观察组48例。给予对照组羟考酮片10 mg/次,3次/d。给予观察组氨酚氢可酮1片,3次/d。治疗5 d后评价疼痛强度和缓解程度,并记录安全性数据比如头晕,恶心和呕吐等。结果治疗前,两组患者VAS评分比较,差异无统计学意义(P>0.05);治疗后,两组VAS评分均较治疗前降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。观察组与对照组的不良反应发生率比较(10.4%比12.8%),差异无统计学意义(P>0.05),且发生不良反应的患者停药后症状均缓解,未出现后遗症。观察组患者治疗满意度高于对照组(98.0%比94.0%),差异无统计学意义(P>0.05)。结论氨酚氢可酮治疗急诊科中重度疼痛效果显著,镇痛效果优于羟考酮,安全可靠,患者满意度高,值得临床推广应用。

Objective To compare the efficacy and safety of hydrocodone and oxycodone in the treatment of severe pain in emergency department. Methods A total of ninety five patients with moderate - severe pain in the emergency department were enrolled and randomly divided into two groups. Forty seven cases in the control group and forty eight cases in the observation group. The control group was given oxyeodone tablets ten milligrams at a time, three times a day. The observation group was given hydroeodone once a day, three times a day. Pain intensity and degree of relief were evaluated after five days and safety data such as dizziness, nausea and vomiting were recorded. Results Before treatment, there was no significant difference in VAS scores between the two groups （ P 〉 0. 05 ）. After treatment, the VAS scores of both groups were lower than those before treatment, and the VAS scores of the two groups were lower than those of the control group （ P 〈 0. 05 ）. There was no significant difference between the observation group and the control group （ 10.4% vs. 12. 8% ） （P 〉0. 05）. Patients with adverse reactions were relieved of symptoms after treatment, with no sequelae. The satisfaction degree of patients in the observation group was higher than that of the control group （98.0% vs. 94. 0% ）, with no significant difference （ P 〉 0. 05 ）. Conclusion Paracetamol and hydrocodone are effective in the treatment of moderate - severe pain in the emergency department. The analgesic effect is superior to oxycodone, safe and reliable, and the patient satisfaction is high, which is worthy of clinical application.